Patents by Inventor Ruth A. Richard

Ruth A. Richard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72
    Patent number: 7179899
    Abstract: Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: February 20, 2007
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V. S. Kashmiri, Liming Shu, Eduardo A. Padlan
  • Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72
    Publication number: 20030165498
    Abstract: Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
    Type: Application
    Filed: September 25, 2002
    Publication date: September 4, 2003
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V.S. Kashmiri, Liming Shu, Eduardo A. Padlan
  • Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains
    Patent number: 6495137
    Abstract: Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: December 17, 2002
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V. S. Kashmiri, Liming Shu, Eduardo A. Padlan
  • Dimer and multimer forms of single chain polypeptides
    Patent number: 6329507
    Abstract: The present invention discloses novel proteins which are dimers and multimers of single chain polypeptides. The single chain polypeptides having two domains derived from the immunoglobulin superfamily which are joined by a peptide linker. The dimers and multimers being formed by non-covalent linking of the single chain polypeptides.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: December 11, 2001
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Ruth A. Richard, Joseph A. Affholter, Nicolas J. Kotite
  • Dimer and multimer forms of single chain polypeptides
    Patent number: 6071515
    Abstract: The present invention discloses novel proteins which are dimers and multimers of single chain polypeptides. The single chain polypeptides having two domains derived from the immunoglobulin superfamily which are joined by a peptide linker. The dimers and multimers being formed by non-covalent linking of the single chain polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 6, 2000
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Ruth A. Richard, Joseph A. Affholter, Nicolas J. Kotite
  • Composite antibodies of human subgroup IV light chain capable of binding to TAG-72
    Patent number: 5976845
    Abstract: This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 2, 1999
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson
  • Composite antibodies of human subgroup IV light chain capable of binding to tag-72
    Patent number: 5976531
    Abstract: This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: November 2, 1999
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson