Patents by Inventor Ruth A. Vrable

Ruth A. Vrable has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine to control equine protozoal myeloencephalitis in horses
    Patent number: 7510720
    Abstract: The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: March 31, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable
  • Vaccine to control equine protozoal myeloencephalitis in horses
    Patent number: 7419668
    Abstract: The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: September 2, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable
  • Vaccine to control equine protozoal myeloencephalitis in horses
    Patent number: 7390492
    Abstract: The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: June 24, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable
  • Antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid
    Patent number: 6344337
    Abstract: The present invention provides an immunoassay to detect identifying antigens in horses that are infected with Sarcocystis neurona. The immunoassay is preferably an antigen-capture-based assay that relies upon polyclonal or monoclonal antibodies against a 16 (±4) and/or 30 (±4) kDa antigens specific to Sarcocystis neurona to detect the presence of the 16 (±4) and/or 30 (±4) kDa antigens in equine serum or equine cerebrospinal fluid.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: February 5, 2002
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable