Patents by Inventor Ruth Christine Matthews
Ruth Christine Matthews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7785571Abstract: A composition comprising an antibody or an antigen binding fragment thereof specific for at least one epitope of hsp90 from an organism of the Aspergillus genus, and at least one antifungal agent selected from the group consisting of: itraconazole and voriconazole.Type: GrantFiled: April 18, 2005Date of Patent: August 31, 2010Assignee: Neutec Pharma LimitedInventors: James Peter Burnie, Ruth Christine Matthews
-
Publication number: 20100055104Abstract: Use of an inhibitor of an hsp 90 protein for the manufacture of a medicament for the treatment or prophylaxis of a condition involving raised levels of TNF? and/or IL-6.Type: ApplicationFiled: January 5, 2007Publication date: March 4, 2010Applicant: Neutec Pharma PLCInventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 7608265Abstract: The present invention is concerned with compounds, medicaments and treatments for Clostridium difficile infection, together with novel isolated antibodies and their use in same. The present invention is also concerned with the treatment and prophylaxis of E. faecium and E. faecalis infection and provides medicaments and treatments for same.Type: GrantFiled: July 1, 2005Date of Patent: October 27, 2009Assignee: NeuTec Pharma Ltd.Inventors: James Peter Burnie, Ruth Christine Matthews, Tracey Carter
-
Publication number: 20080171054Abstract: The present invention is concerned with novel antibodies, medicaments, pharmaceutical packs, methods of manufacture of medicaments and methods for the treatment of micro-organism infections, particularly for the treatment of Staphylococcal infections such as S. aureus infections including MRSA infections.Type: ApplicationFiled: October 31, 2007Publication date: July 17, 2008Inventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 7132512Abstract: The present invention concerns treatment, prevention and diagnosis of infection due to Chlamydia pneumoniae and, in particular, to the prevention and treatment of atherosclerosis, including coronary atherosclerosis, caused by same.Type: GrantFiled: August 6, 2003Date of Patent: November 7, 2006Assignee: NeuTec Pharma PLCInventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 6881410Abstract: The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods of same and kits for performing same. Also provided are immunodominant conserved antigens from gram positive staphylococci, together with neutralising and binding agents specific thereto for use in therapy and diagnosis, and methods of same. Also provided are Staphylococcal holomogues of IstA and IstB and immunogenic fragments thereof, and their uses in methods of treatment and diagnosis of the human or animal body.Type: GrantFiled: January 25, 2002Date of Patent: April 19, 2005Assignee: Neu Tec Pharma PLCInventors: James Peter Burnie, Ruth Christine Matthews
-
Publication number: 20030119101Abstract: The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods of same and kits for performing same. Also provided are immunodominant conserved antigens from gram positive staphylococci, together with neutralising and binding agents specific thereto for use in therapy and diagnosis, and methods of same. Also provided are Staphylococcal holomogues of IstA and IstB and immunogenic fragments thereof, and their uses in methods of treatment and diagnosis of the human or animal body.Type: ApplicationFiled: January 25, 2002Publication date: June 26, 2003Applicant: NeuTec Pharma plc.Inventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 6544516Abstract: The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralizing agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods of same and kits for performing same. Also provided are immunodominant conserved antigens from gram positive staphylococci, together with neutralising and binding agents specific thereto for use in therapy and diagnosis, and methods of same. Also provided are Staphylococcal homologues of IstA and IstB and immunogenic fragment thereof, and their uses in methods of treatment and diagnosis of the human or animal body.Type: GrantFiled: January 4, 1999Date of Patent: April 8, 2003Assignee: NeuTec Pharma plcInventors: James Peter Burnie, Ruth Christine Matthews
-
Publication number: 20030065145Abstract: The present invention concerns immunogenic epitopes of Shigella-like toxins (SLTs), particularly the Shigella-like toxin of E. coli O157:H7, their use as immunogens and in treatment or diagnosis, agents (for example antibodies and antigen-binding fragments) which specifically neutralise them, their use in treatment and diagnosis, and methods for same.Type: ApplicationFiled: May 30, 2002Publication date: April 3, 2003Applicant: NeuTech Pharma PLCInventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 6410024Abstract: The present invention concerns immunogenic epitopes of Shigella-like toxins (SLTs), particularly the Shigella-like toxin of E. coli 0157:H7, their use as immunogens and in treatment or diagnosis, agents (for example antibodies and antigen-binding fragments) which specifically neutralise them, their use in treatment and diagnosis, and methods for same.Type: GrantFiled: January 20, 2000Date of Patent: June 25, 2002Assignee: NeuTech Pharma PLCInventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 5861157Abstract: The present invention provides a purified bacterial protein expressed during infection due to streptococci or enterococci and isolated from human sera, together with immunogenic fragments, analogs, inhibitors, antibodies and antigenic fragments specific thereto. Also provided is a DNA sequence coding for a bacterial protein or an immunogenic fragment or an analogue thereof expressed during infection due to Streptococci or Enterococci, together with homologues thereof, together with vectors, probes and inhibitors therefor. Also provided is fibronectin or an immunogenic fragment thereof or an analogue thereof or an antibody thereto or an anigen binding fragment thereof when used in a method of treatment or diagnosis of the human or animal body for infection due to Streptococci or Enterococci.Type: GrantFiled: July 29, 1996Date of Patent: January 19, 1999Assignee: NeuTec Pharma plcInventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 5777083Abstract: A functional epitope which is purified from human HSP 90 or which is synthesised to correspond to such a purified epitope, which is, if purified, unchanged or changed by substitution of selected amino acids and if synthesised is identical to a purified epitope or differs from a purified epitope by substitution of selected amino acids, and which cross-reacts with an antibody raised against a stress protein.Type: GrantFiled: April 10, 1995Date of Patent: July 7, 1998Assignee: NeuTec Pharma PlcInventors: James Peter Burnie, Ruth Christine Matthews
-
Patent number: 5686248Abstract: A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organisms, particularly the heat shock protein hsp 90 of Saccharomyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.Type: GrantFiled: June 28, 1996Date of Patent: November 11, 1997Assignee: The Victoria University of ManchesterInventors: James Peter Burnie, Ruth Christine Matthews