Patents by Inventor Ruth E. Tenbrink

Ruth E. Tenbrink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[2,3-D]pyrimidine derivatives
    Patent number: 9549929
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: January 24, 2017
    Assignee: Pfizer Inc.
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
  • Pyrrolo[2,3-D]pyrimidine derivatives
    Patent number: 9545405
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: January 17, 2017
    Assignee: Pfizer Inc.
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20150246048
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 3, 2015
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20150225408
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Application
    Filed: April 21, 2015
    Publication date: August 13, 2015
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
  • Pyrrolo[2,3-D]pyrimidine derivatives
    Patent number: 9035074
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: May 19, 2015
    Assignee: Pfizer Inc.
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20140243312
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Application
    Filed: February 19, 2014
    Publication date: August 28, 2014
    Applicant: Pfizer Inc.
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez
  • Substituted hydroxyethylamines
    Patent number: 7498436
    Abstract: This present invention relates to prodrug compounds of the formula (Y) and pharmaceutical salts thereof: where RN, R1, R2, R3R4 and RC are defined herein, which are useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: March 3, 2009
    Assignees: Pharmacia & Upjohn Company LLC, Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Barbara Jagodzinska, Michel Maillard, James P. Beck, Ruth E. TenBrink, Daniel Getman
  • Macrocycles useful in the treatment of alzheimer's disease
    Patent number: 7456163
    Abstract: The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: November 25, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Macrocycles useful in the treatment of alzheimer's disease
    Patent number: 7442691
    Abstract: The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: October 28, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • Compounds to treat Alzheimer's disease
    Patent number: 7214715
    Abstract: The present invention is substituted amines of formula (X) and of the formula (X?) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: May 8, 2007
    Assignees: Pharmacia & Upjohn, Elan Pharmaceuticals
    Inventors: James P. Beck, Lawrence Y. Fang, John N. Freskos, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard, Shon R. Pulley, Ruth E. TenBrink
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 7067507
    Abstract: The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 6969709
    Abstract: The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: November 29, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • Pyridyl sulfone derivatives
    Patent number: 6855709
    Abstract: The invention provides compounds of the formula and methods of using those compounds for treating a disease or condition in a mammal wherein a 5-HT receptor, such as a 5-HT6 receptor, is implicated and modulation of a 5-HT function is desired, wherein A, G and W1-W3 are defined as herein.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: February 15, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ruth E. Tenbrink, Steven W. Kortum
  • Mycrocycles useful in the teatment of Alzheimer's disease
    Publication number: 20030236199
    Abstract: The present invention are macrocycles of the formula (IX): 1
    Type: Application
    Filed: June 12, 2002
    Publication date: December 25, 2003
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • Macrocycles useful in the treatment of alzheimer's disease
    Publication number: 20030236240
    Abstract: The present invention is macrocycles of the formula (X): 1
    Type: Application
    Filed: June 13, 2002
    Publication date: December 25, 2003
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Arylsulfone derivatives
    Publication number: 20030220325
    Abstract: The invention provides compounds of the formula 1
    Type: Application
    Filed: February 20, 2003
    Publication date: November 27, 2003
    Inventors: Ruth E. Tenbrink, Steven W. Kortum
  • Pyridyl sulfone derivatives
    Publication number: 20030186968
    Abstract: The invention provides compounds of the formula 1
    Type: Application
    Filed: February 20, 2003
    Publication date: October 2, 2003
    Inventors: Ruth E. Tenbrink, Steven W. Kortum
  • Compounds to treat alzheimer's disease
    Publication number: 20020128255
    Abstract: The present invention is substituted amines of formula (X) 1
    Type: Application
    Filed: June 29, 2001
    Publication date: September 12, 2002
    Inventors: James P. Beck, Lawrence Y. Fang, John N. Freskos, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard, Shon R. Pulley, Ruth E. TenBrink
  • Heterocyclic compounds for the treatment of CNS and cardiovascular disorders
    Patent number: 6133446
    Abstract: Novel aromatic bicyclic amines of formula (I) ##STR1## are useful in treating central nervous system disorders and cardiac arrhythmias and cardiac fibrillation.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: October 17, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ruth E. TenBrink, Michael D. Ennis, Chiu-Hong Lin, Robert A. Lahti, Arthur G. Romero, John C. Sih
  • Imidazo?1,2-a!pyridines for the treatment of CNS and cardiac diseases
    Patent number: 5912246
    Abstract: The present invention relates to imidazo?1,2-a!pyridine compounds of formula (1) ##STR1## which are dopamine D-4 antagonists and useful as anti-psychotic agents.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: June 15, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventor: Ruth E. Tenbrink