Patents by Inventor Ruth Foelsche Nutt

Ruth Foelsche Nutt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors
    Patent number: 6034215
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: March 7, 2000
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Robert John Ardecky, Ruth Foelsche Nutt, William Charles Ripka, David C. Rowley, Marguerita S. L. Lim-Wilby, Terence Kevin Brunck
  • N-substituted glycine derivatives as enzyme inhibitors
    Patent number: 6025472
    Abstract: The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 15, 2000
    Assignee: Corvas International, Inc.
    Inventors: Matthew Mark Abelman, Todd Anthony Miller, Ruth Foelsche Nutt
  • Arginine mimic derivatives as enzyme inhibitors
    Patent number: 5883107
    Abstract: The present invention provides peptide aldehydes having an azetidinyl, prolyl or pipecolyl group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 16, 1999
    Assignee: Corvas International, Inc.
    Inventors: Odile Esther Levy, Susan Yoshiko Tamura, Ruth Foelsche Nutt, William Charles Ripka
  • Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
    Patent number: 5770600
    Abstract: This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 23, 1998
    Assignee: Corvas International, Inc.
    Inventors: Matthew Mark Abelman, Robert John Ardecky, Ruth Foelsche Nutt
  • Method of synthesis of peptidyl aldehydes
    Patent number: 5731413
    Abstract: This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to ?novel! reagents useful therein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 24, 1998
    Assignee: Corvas International, Inc.
    Inventors: Thomas Roy Webb, John Eugene Reiner, Susan Yoshiko Tamura, William Charles Ripka, Raymond Dagnino, Jr., Ruth Foelsche Nutt
  • 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
    Patent number: 5703208
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Robert John Ardecky, Ruth Foelsche Nutt, William Charles Ripka, David C. Rowley, Marguerita S. L. Lim-Wilby, Terence Kevin Brunck
  • N-substituted glycine derivatives as enzyme inhibitors
    Patent number: 5696231
    Abstract: The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: December 9, 1997
    Assignee: Corvas International, Inc.
    Inventors: Matthew Mark Abelman, Todd Anthony Miller, Ruth Foelsche Nutt
  • Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
    Patent number: 5658939
    Abstract: This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: August 19, 1997
    Assignee: Corvas International Inc.
    Inventors: Matthew Mark Abelman, Robert John Ardecky, Ruth Foelsche Nutt