Patents by Inventor Ruth Gjerset

Ruth Gjerset has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Down-regulation of DNA repair to enhance sensitivity to p53-mediated suppression
    Publication number: 20050095226
    Abstract: The present invention details methods for the treatment of cancer. In particular, it concerns the induction of apoptosis in cancer cells following treatment with inhibitors of DNA repair in combination with p53 gene therapy. Treatment of glioblastoma and breast tumor cells with inhibitors of DNA repair induced growth suppression that was a result of p53-mediated apoptosis. Thus it appears that inhibitors of DNA repair in combination with p53 gene therapy is involved in restoration of p53-mediated apoptosis.
    Type: Application
    Filed: May 10, 2004
    Publication date: May 5, 2005
    Inventor: Ruth Gjerset
  • Tumor suppression through bicistronic co-expression of p53 and p14ARF
    Publication number: 20050032728
    Abstract: A bicistronic construct of p53 and p14ARF, vectors and other delivery vehicles which include the bicistronic construct, and methods of treating cancer using the vectors and bicistronic construct.
    Type: Application
    Filed: November 19, 2003
    Publication date: February 10, 2005
    Inventors: Ruth Gjerset, Yinghui Huang, Neshat Saadatmandi
  • Enhancing the sensitivity of tumor cells to therapies
    Publication number: 20040072775
    Abstract: A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.
    Type: Application
    Filed: February 25, 2003
    Publication date: April 15, 2004
    Inventors: Robert Sobol, Ruth Gjerset
  • Enhancing the sensitivity of tumor cells to therapies
    Publication number: 20020010144
    Abstract: A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.
    Type: Application
    Filed: January 10, 2001
    Publication date: January 24, 2002
    Inventors: Robert Sobol, Ruth Gjerset
  • Enhancing the sensitivity of tumor cells to therapies
    Publication number: 20020006914
    Abstract: A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.
    Type: Application
    Filed: January 26, 2001
    Publication date: January 17, 2002
    Inventors: Robert E. Sobol, Ruth Gjerset