Patents by Inventor Ruth McAdam

Ruth McAdam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insertional mutations in mycobacteria
    Patent number: 6752994
    Abstract: A mutated mycobacterium selected from the class consisting of mutated M. bovis-BCG, mutated M. tuberculosis, and mutated M. leprae. The mutation of M. bovis-BCG, M. tuberculosis, or M. leprae is preferably effected through an insertional mutation of a mycobacterial gene. The insertional mutagenesis may be effected, for example, through illegitimate recombination or by a mycobacterial transposon. Such mutated mycobacteria may then be transformed with an expression vector(s) containing a complement gene to the gene which is mutated, and preferably also including a heterologous gene.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: June 22, 2004
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: William R. Jacobs, Jr., Barry Bloom, Ganjam V. Kalpana, Jeffrey D. Cirillo, Ruth McAdam
  • Insertional mutations in mycobacteria
    Publication number: 20030100100
    Abstract: A mutated mycobacterium selected from the class consisting of mutated M. bovis-BCG, mutated M. tuberculosis, and mutated M. leprae. The mutation of M. bovis-BCG, M. tubeiculosis, or M. leprae is preferably effected through an insertional mutation of a mycobacterial gene. The insertional mutagenesis may be effected, for example, through illegitimate recombination or by a mycobacterial transposon. Such mutated mycobacteria may then be transformed with an expression vector(s) containing a complement gene to the gene which is mutated, and preferably also including a heterologous gene.
    Type: Application
    Filed: July 3, 2001
    Publication date: May 29, 2003
    Inventors: William R. Jacobs, Barry Bloom, Ganjam V. Kalpana, Jeffrey D. Cirillo, Ruth McAdam
  • Insertional mutations in mycobacteria
    Patent number: 6566121
    Abstract: A mutated mycobacterium selected from the class consisting of mutated M.bovis-BCG, mutated M.tuberculosis, and mutated M. leprae. The mutation of M.bovis-BCG, M.tuberculosis, or M. leprae is preferably effected through an insertional mutation of a mycobacterial gene. The insertional mutagenesis may be effected, for example, through illegitimate recombination or by a mycobacterial transposon. Such mutated mycobacteria may then be transformed with an expression vector(s) containing a complement gene to the gene which is mutated, and preferably also including a heterologous gene.
    Type: Grant
    Filed: May 5, 1997
    Date of Patent: May 20, 2003
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: William R. Jacobs, Jr., Barry Bloom, Ganjam V. Kalpana, Jeffrey D. Cirillo, Ruth McAdam
  • L5 shuttle phasmids
    Patent number: 5994137
    Abstract: This invention is directed to L5 shuttle phasmids capable of delivering foreign DNA into mycobacteria and to methods of producing L5 shuttle phasmids. In addition, this invention is directed to a method of generating mycobacterial mutations and to a method of producing mycobacterial vaccines.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: November 30, 1999
    Assignees: Albert Einstein College of Medicine of Yeshiva University, University of Pittsburgh
    Inventors: William R. Jacobs, Graham F. Hatfull, Stoyan Bardarov, Ruth McAdam
  • L5 shuttle phasmids
    Patent number: 5750384
    Abstract: This invention is directed to L5 shuttle phasmids capable of delivering foreign DNA into mycobacteria and to methods of producing L5 shuttle phasmids. In addition, this invention is directed to a method of generating mycobacterial mutations and to a method of producing mycobacterial vaccines.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: May 12, 1998
    Assignees: Albert Einstein College of Medicine of Yeshiva University, a division of Yeshiva University, University of Pittsburgh
    Inventors: William R. Jacobs, Graham F. Hatfull, Stoyan Bardarov, Ruth McAdam