Patents by Inventor Ruth Moysey

Ruth Moysey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED HELICASES
    Publication number: 20230227799
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 18, 2022
    Publication date: July 20, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • MODIFIED HELICASES
    Publication number: 20230212535
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 17, 2022
    Publication date: July 6, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • Enzyme method
    Patent number: 11634763
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: April 25, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Ruth Moysey, Andrew John Heron
  • Modified helicases
    Patent number: 11525125
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: December 13, 2022
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Mark John Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • Modified helicases
    Patent number: 11525126
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: December 13, 2022
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark John Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Antoni Alves, Rebecca Victoria Bowen, John Milton
  • ENZYME METHOD
    Publication number: 20220372568
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or a molecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.
    Type: Application
    Filed: May 31, 2022
    Publication date: November 24, 2022
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Ruth Moysey, Andrew John Heron
  • SSB METHOD
    Publication number: 20220145383
    Abstract: The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (SSB). The SSB is either an SSB comprising a carboxy-terminal (C-terminal) region which does not have a net negative charge or a modified SSB comprising one or more modifications in its C-terminal region which decreases the net negative charge of the C-terminal region.
    Type: Application
    Filed: September 22, 2021
    Publication date: May 12, 2022
    Applicant: Oxford Nanopore Technologies Limited
    Inventors: James White, Ruth Moysey, Mihaela Misca
  • SSB method
    Patent number: 11155860
    Abstract: The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (SSB). The SSB is either an SSB comprising a carboxy-terminal (C-terminal) region which does not have a net negative charge or a modified SSB comprising one or more modifications in its C-terminal region which decreases the net negative charge of the C-terminal region.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: October 26, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: James White, Ruth Moysey, Mihaela Misca
  • ENZYME METHOD
    Publication number: 20210172011
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or a molecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.
    Type: Application
    Filed: June 16, 2020
    Publication date: June 10, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Ruth Moysey, Andrew John Heron
  • MODIFIED HELICASES
    Publication number: 20210123032
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 29, 2021
    Applicant: Oxford Nanopore Technologies Limited
    Inventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Alves, Rebecca Bowen, John Milton
  • MODIFIED HELICASES
    Publication number: 20210009971
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: June 4, 2020
    Publication date: January 14, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • Modified helicases
    Patent number: 10808231
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: October 20, 2020
    Assignee: Oxford Nanopore Technologies Limited
    Inventors: Andrew Heron, James Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Alves, Rebecca Bowen, John Milton
  • Modified helicases
    Patent number: 10724018
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: July 28, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Mark John Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • Enzyme method
    Patent number: 10724087
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 28, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Ruth Moysey, Andrew John Heron
  • Enzyme method
    Patent number: 10385382
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a RecD helicase. The helicase controls the movement of the target polynucleotide through the pore.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 20, 2019
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Ruth Moysey, Andrew John Heron, Szabolcs Soeroes
  • ENZYME CONSTRUCT
    Publication number: 20180230526
    Abstract: The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 16, 2018
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, James Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, Mihaela Misca
  • ENZYME METHOD
    Publication number: 20180216175
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.
    Type: Application
    Filed: August 11, 2017
    Publication date: August 2, 2018
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Ruth Moysey, Andrew John Heron
  • MODIFIED HELICASES
    Publication number: 20180037874
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: September 10, 2014
    Publication date: February 8, 2018
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • ENZYME METHOD
    Publication number: 20180030530
    Abstract: The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.
    Type: Application
    Filed: August 11, 2017
    Publication date: February 1, 2018
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Ruth Moysey, Andrew John Heron
  • Enzyme construct
    Patent number: 9797009
    Abstract: The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: October 24, 2017
    Assignee: Oxford Nanopore Technologies Limited
    Inventors: Andrew Heron, James Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, Mihaela Misca