Patents by Inventor Ruth R. Wexler

Ruth R. Wexler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of imidazoles for the treatment of atherosclerosis
    Patent number: 5166214
    Abstract: This invention relates to imidazoles as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), processes for their preparation, and their use as antihypercholesterolemic agents or antiatherosclerotic.The compounds for use in the described method are compounds of Formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are selected independently from H, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 branched alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.4 -C.sub.10 cycloalkylalkyl, C.sub.7 -C.sub.14 araalkyl, phenyl optionally substituted with 1 to 3 groups selected from F, Cl, Br, OH, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.8 branched alkyl, CH.sub.3 S(O).sub.r, NO.sub.2, CF.sub.3, or NR.sup.7 R.sup.8 ; R.sup.3 is H, C.sub.1 -C.sub.6 alkyl, allyl, benzyl, or phenyl optionally substituted with F, Cl, CH.sub.3, CH.sub.3 O, or CF.sub.3 ; R.sup.4 is straight chain C.sub.1 -C.sub.8 alkyl optionally substituted with F; C.sub.3 -C.sub.8 branched alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.4 -C.sub.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: November 24, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Jeffrey T. Billheimer, Peter J. Gillies, C. Anne Higley, Thomas P. Maduskuie, Jr., Ruth R. Wexler
  • Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
    Patent number: 5091390
    Abstract: Provided are 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AII type-2 receptors in the central nervous system.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: February 25, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, Andrew T. Chiu, John J. V. Duncia, Petrus B. M. W. M. Timmermans, Ruth R. Wexler
  • 1,4-dihydropyridine derivatives with calcium agonist and alpha.sub.1 -antagonist activity
    Patent number: 4868181
    Abstract: 1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha.sub.1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the formula: ##STR1## wherein Ar, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined in the specification.
    Type: Grant
    Filed: June 30, 1987
    Date of Patent: September 19, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Alexander L. Johnson, Philip Ma, Petrus B. M. W. M. Timmermans, Ruth R. Wexler
  • Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
    Patent number: 4632930
    Abstract: Antihypertensive alkyl-arylheterocycle methanol or methanamine derivatives are useful in the treatment of hypertension.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: December 30, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, Ruth R. Wexler
  • Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives
    Patent number: 4576958
    Abstract: Antihypertensive 4-phenyl-5-(4-methylsulfonylphenyl)-.alpha.,.alpha.-bis(trifluoromethyl)-1 H-imidazole-2-methanol derivatives are useful in the treatment of hypertension.
    Type: Grant
    Filed: January 23, 1984
    Date of Patent: March 18, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Ruth R. Wexler