Abstract: A computerized method of generating evidence based case object for a decision support application. The method comprises providing a medical decision point, generating a decision point model mapping between a plurality of patient dependent clinical characteristics and a plurality of treatment options for the medical decision point according to a plurality of guidelines, estimating, using a processor, a plurality of treatment outcomes for each the treatment option, each the treatment outcome being estimated according to an analysis of medical records of a group of patients been at the medical decision point and having a subset of the plurality of patient dependent clinical characteristics selected from a plurality of subsets, and generating evidence based case object which receive patient data having patient dependent clinical characteristics matching one of the plurality of subsets and outputs an estimated prognosis based on a respective treatment outcome from the plurality of treatment outcomes.