Patents by Inventor Ruth Sager

Ruth Sager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Maspin transcriptional regulatory sequences and uses thereof
    Patent number: 6960658
    Abstract: Isolated nucleic acid molecules that include transcriptional regulatory sequences of the maspin gene are described. These nucleic acid molecules are useful for identifying compounds and proteins that alter expression of maspin in mammary cells and other cell types.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: November 1, 2005
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Arthur Pardee, Ming Zhang, Ruth Sager
  • Maspin, a serpin with tumor suppressing activity
    Patent number: 5905023
    Abstract: An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 18, 1999
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ruth Sager, Zhiqiang Zou, Anthony Anisowicz
  • Method of detecting cancer
    Patent number: 5801001
    Abstract: An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 1, 1998
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ruth Sager, Zhiqiang Zou, Anthony Anisowicz
  • Cancer diagnosis using nucleic acid hybridization
    Patent number: 5688641
    Abstract: A method of determining whether a test cell from a given human tissue type is (a) normal, or (b) cancerous or precancerous, by contacting the mRNA of the test cell with a nucleic acid probe which contains a nucleotide sequence at least 15 nucleotides in length which is complementary to a portion of the coding sequence of a candidate tumor suppressor gene, which gene is one that is expressed at a given control level in normal cells of that tissue type; and determining the approximate amount of hybridization of the probe to the mRNA of the test cell, an amount of hybridization one-third or less that seen with the mRNA of a normal cell of that tissue type being an indication that the test cell is cancerous or precancerous. Alternatively, an antibody specific for the candidate tumor suppressor gene product can be substituted for the nucleic acid probe as a means for determining the level of expression of the gene in the test cell.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: November 18, 1997
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ruth Sager, Zhiqiang Zou, Sam Whan Lee, Catherine Laure Tomasetto
  • Maspin, a serpin with tumor suppresing activity
    Patent number: 5470970
    Abstract: An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
    Type: Grant
    Filed: September 1, 1993
    Date of Patent: November 28, 1995
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ruth Sager, Anthony Anisowicz, Zhiqiang Zou
  • cDNA probe differentiating normal and cancer tissues
    Patent number: 5262528
    Abstract: Nucleic acid encoding clone 19 gene product, and protein which interacts specifically with an antibody specific to the gene product of clone 19.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: November 16, 1993
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ruth Sager, Sam W. Lee, Catherine Tomasetto
  • Promotion of maturation of hematopoietic progenitor cells
    Patent number: 5154921
    Abstract: A method for promoting maturation of a hematopoietic precursor cell of an animal, which method includes the step of contacting the cell with a maturation-promoting amount of GRO, a polypeptide growth factor.
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: October 13, 1992
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ruth Sager, Douglas Trask, Phong Le