Abstract: The invention provides a method for imaging samples, at least comprising: —staining of a sample with a first marker material and with a second marker material; —utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and —utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.

Abstract: There is provided a microelectronic sensor device (100) for the detection of target components (10) near a binding surface (12), comprising a source (21) for emitting a beam (101) of radiation having a wavelength incident at the binding surface (12); an optical structure (11) near the binding surface (12), for providing evanescent radiation, in response to the radiation incident at the binding surface (12), in a detection volume (4) bound by the binding surface (12) and extending over a decaylength away from the binding surface (12) into a sample chamber (2); and a detector (31) for detecting radiation (102) from the target component (10)1 present in the detection volume (4), in response to the emitted incident radiation (101) from the source (21) wherein the binding surface (12) is provided with upstanding walls of a dielectric material (3), for providing one or more detection volumes (4) bound to a maximum in plane detection volume dimension (W1) smaller than a diffraction limit, the diffraction limit defin

Abstract: The invention provides a method for imaging samples, at least comprising:—staining of a sample with a first marker material and with a second marker material;—utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and—utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.

Abstract: It is described a device (100) for analyzing biological cell material (115). The device (100) comprises a light source arrangement (120), which is adapted for directing a first (131) and a second illumination light (132) towards the cell material (115), wherein the first (131) and the second (132) illumination light comprises a first and a second spectral radiation component, respectively. The device (100) further comprises a detector arrangement (170), which is adapted for receiving a first measurement light (151) based on a first interaction of the first illumination light (131) with the cell material (115) and a second measurement light (152) based on a second interaction of the second illumination light (152) with the cell material (115).

Abstract: This application describes a medical device (230) for obtaining optical tissue properties of a target material. The medical device (230) comprises an elongated body (231) having a longitudinal axis (232) and an optical fiber being integrated within the elongated body (231). The optical fiber has a second fiber end (242, 242a, 242b), which is arranged at a side wall (233) of the elongated body (231) and which provides a lateral field of view with respect to the longitudinal axis (232). According to an embodiment many optical fibers are integrated each having an optical outlet (242, 242a, 242b) around the elongated body (231). Using the outlets (242, 242a, 242b) to do diffuse optical tomography and also use optical fibers to do an optical inspection, one can get information on the presence of tumors in a volume around the medical device (230) and a tissue characterization in the vicinity of the medical device (230). Thereby, an optical biopsy may be carried out, wherein no real tissue is removed.