Patents by Inventor Ruthann M. Smejkal

Ruthann M. Smejkal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbaphens: aprophen analogs that are binary antidotes for organophosphate poisoning
    Patent number: 5026897
    Abstract: Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof.Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well.Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: June 25, 1991
    Assignee: The United States of America, as represented by the Secretary of the Army
    Inventors: Peter K. Chiang, Haim Leader, Ruthann M. Smejkal, Richard K. Gordon, Charlotte S. Payne, Bhupendra P. Doctor, Felipe N. Padilla