Patents by Inventor Ruthann Nichols

Ruthann Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RFamide-related peptides and methods thereof
    Patent number: 9527889
    Abstract: Provided herein methods and compositions directed to RFRP-1 polypeptides for modulating cardiac contractile function, for preventing and/or treating cardiac disorders.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: December 27, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ruthann Nichols, Margaret Westfall
  • RFAMIDE-RELATED PEPTIDES AND METHODS THEREOF
    Publication number: 20150183829
    Abstract: Provided herein methods and compositions directed to RFRP-1 polypeptides for modulating cardiac contractile function, for preventing and/or treating cardiac disorders.
    Type: Application
    Filed: December 24, 2014
    Publication date: July 2, 2015
    Inventors: RUTHANN NICHOLS, MARGARET WESTFALL
  • RFamide-Related Peptides and Methods Thereof
    Publication number: 20130116184
    Abstract: Provided herein methods and compositions directed to RFRP-1 polypeptides for modulating cardiac contractile function, for preventing and/or treating cardiac disorders.
    Type: Application
    Filed: March 31, 2011
    Publication date: May 9, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ruthann Nichols, Margaret Westfall
  • Oligonucleotides having universal nucleoside spacers
    Patent number: 5681947
    Abstract: Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: October 28, 1997
    Assignees: Purdue Research Foundation, The Regents of the University of Michigan
    Inventors: Donald Eugene Bergstrom, Philip Charles Andrews, Ruthann Nichols, Peiming Zhang
  • 3-nitropyrrole nucleoside
    Patent number: 5438131
    Abstract: Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: August 1, 1995
    Inventors: Donald E. Bergstrom, Philip C. Andrews, Ruthann Nichols, Peiming Zhang