Patents by Inventor Ruud Martin VERSTEGEN

Ruud Martin VERSTEGEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purifying Cys-linked antibody-drug conjugates
    Patent number: 10266606
    Abstract: The present invention relates to a method for purifying a mixture of cysteine-linked antibody-drug conjugates, wherein the amount of non-conjugated antibody is in the range of 0-40% by weight, using hydrophobic interaction chromatography (HIC). The mixture is loaded onto a preparative HIC column using a 0.2-1.5 M aqueous salt solution, in which non-conjugated antibody is collected in a flow-through fraction, followed by elution of a purified mixture of cysteine-linked antibody-drug conjugates using a 0-100 mM aqueous salt solution.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: April 23, 2019
    Assignee: Synthon Biopharmaceuticals B.V.
    Inventors: Guy De Roo, Ruud Martin Verstegen, Rudy Gerardus Elisabeth Coumans
  • METHOD FOR PURIFYING CYS-LINKED ANTIBODY-DRUG CONJUGATES
    Publication number: 20160324979
    Abstract: The present invention relates to a method for purifying a mixture of cysteine-linked antibody-drug conjugates, wherein the amount of non-conjugated antibody is in the range of 0-40% by weight, using hydrophobic interaction chromatography (HIC). The mixture is loaded onto a preparative HIC column using a 0.2-1.5 M aqueous salt solution, in which non-conjugated antibody is collected in a flow-through fraction, followed by elution of a purified mixture of cysteine-linked antibody-drug conjugates using a 0-100 mM aqueous salt solution.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 10, 2016
    Applicant: SYNTHON BIOPHARMACEUTICALS B.V.
    Inventors: Guy DE ROO, Ruud Martin VERSTEGEN, Rudy Gerardus Elisabeth COUMANS