Patents by Inventor Ruurd Van der Zee

Ruurd Van der Zee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment and prevention of inflammatory diseases and autoimmune diseases
    Patent number: 8742068
    Abstract: The present invention relates to the use of fragments of heat shock proteins for the treatment and/or prevention of autoimmune diseases such as arthritis or inflammatory diseases such as Inflammatory Bowel Diseases. Preferably bacterial and/or mammalian heat shock proteins belonging to the HSP70 families are used.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: June 3, 2014
    Assignee: Universiteit Utrecht Holding B.V.
    Inventors: Willem van Eden, Ruurd van der Zee
  • TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES
    Publication number: 20100329985
    Abstract: The present invention relates to the use of fragments of heat shock proteins for the treatment and/or prevention of autoimmune diseases such as arthritis or inflammatory diseases such as Inflammatory Bowel Diseases. Preferably bacterial and/or mammalian heat shock proteins belonging to the HSP70 families are used.
    Type: Application
    Filed: July 7, 2008
    Publication date: December 30, 2010
    Inventors: Willem Van Eden, Ruurd Van Der Zee
  • TREATMENT AND PREVENTION OF INFLAMMATORY BOWEL DISEASES
    Publication number: 20090118173
    Abstract: The present invention relates to the use of heat shock proteins, or fragments thereof, for the treatment and/or prevention of Inflammatory Bowel Diseases. Preferably bacterial and/or mammalian heat shock proteins belonging to the HSP70 families are used.
    Type: Application
    Filed: July 6, 2007
    Publication date: May 7, 2009
    Inventors: Willem van Eden, Ruurd van der Zee, Helena Tlaskalova-Hogenova, Miloslav Kverka
  • TREATMENT AND PREVENTION OF INFLAMMATORY BOWEL DISEASES
    Publication number: 20080039400
    Abstract: The present invention relates to the use of heat shock proteins, or fragments thereof, for the treatment and prevention of Inflammatory Bowel Diseases. Preferably bacterial and/or human heat shock proteins, especially those belonging to the HSP60 family, are used.
    Type: Application
    Filed: January 23, 2007
    Publication date: February 14, 2008
    Inventors: Willem VAN EDEN, Ruurd Van Der Zee, Helena Tlaskalova-Hogenova, Miloslav Kverka
  • Polypeptides and derivatives thereof as well as their use in pharmaceutical and diagnostic compositions
    Patent number: 5354691
    Abstract: A polypeptide having amino acid sequence 172-192 of a Mycobacterium bovis BCG 64 kD polypeptide, said sequence having the formula ##STR1## as well as polypeptides derived therefrom, in the amino acid sequence of which sequence 172-179 and/or sequence 189-192 is (are) entirely or partially absent, were found to be useful as immunogens inducing resistance to auto-immune arthritis and similar auto-immune diseases.The invention relates to these polypeptides, to polypeptides showing sequential homology with these polypeptides, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer form part of the invention.Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: October 11, 1994
    Assignees: De Staat der Nederlanden Vertegenwoordigd Voor de Minister Van Welzijn, Volksgezondheid en Cultuur, Riksuniversiteit Te Utrecht, Yeda Research and Development Co., Ltd.
    Inventors: Willem Van Eden, Johannes D. A. Van Embden, Ruurd Van Der Zee, Irun R. Cohen
  • Methods of treatment and diagnosis of autoimmune diseases, especially arthritic conditions
    Patent number: 5268170
    Abstract: A Mycobacterium bovis BCG polypeptide having a molecular mass of about 64 kD was found to be useful as an immunogen inducing resistance to autoimmune arthritis and similar autoimmune diseases.The invention relates to methods of treatment and diagnosis of autoimmune diseases especially arthritic conditions, in which said polypeptide is used.The invention also relates to a polypeptide comprising the epitope essential for this activity. The polypeptide has the formula ##STR1## Further, the invention relates to polypeptides showing sequential homology with said polypeptide, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer, form part of the invention.Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: December 7, 1993
    Assignee: YEDA Research and Development Co., Ltd.
    Inventors: Willem Van Eden, Jelle E. R. Thole, Johannes D. A. Van Embden, Ruurd Van Der Zee, Irun R. Cohen
  • Polypeptides and derivatives thereof as well as their use in pharmaceutical and diagnostic compositions
    Patent number: 5154923
    Abstract: A polypeptide having amino acid sequence 172-192 of a Mycobacterium bovis BCG 64 kD polypeptide, said sequence having the formula ##STR1## as well as polypeptides derived therefrom, in the amino acid sequence of which sequence 172-179 and/or sequence 189-192 is (are) entirely or partially absent, were found to be useful as immunogens inducing resistance to auto-immune arthritis and similar auto-immune diseases.The invention relates to these polypeptides, to polypeptides showing sequential homology with these polypeptides, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer form part of the invention.Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: October 13, 1992
    Assignees: De Staat Der Nederlanden Vertegenwoordigd Door de Minister Van Welzijn, Volksgezondheid En Cultuur, Rijksuniversiteit Te Utrecht, Yeda Research and Development Co. Ltd.
    Inventors: Willem Van Eden, Johannes D. A. Van Embden, Ruurd Van der Zee, Irun R. Cohen