Patents by Inventor Ruxiu Liu

Ruxiu Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12370548
    Abstract: Embodiments of the microfluidic device may include of an array of microfluidic cell capture chambers, each functionalized with a different antibody to recognize a target antigen, and a network of code-multiplexed Coulter counters placed at strategic nodes across the device to quantify the fraction of cell population captured in each microfluidic chamber. For example, an apparatus may comprise a fluid inlet port divided into a plurality of separate microfluidic paths, each separate microfluidic path configured to transport a plurality of cells, the plurality of separate microfluidic paths, each comprising a plurality of microfluidic cell capture chambers, an outlet port to discharge a merged output of cells from the plurality of microfluidic cell capture chambers, and a plurality of sensors to detect cells passing into or out of a microfluidic cell capture chamber.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: July 29, 2025
    Assignee: Georgia Tech Research Corporation
    Inventors: Ali Fatih Sarioglu, Ruxiu Liu
  • Publication number: 20250214078
    Abstract: Systems and methods to integrate electrical sensors comprising parallel electrodes into microfluidic devices that are manufactured using soft lithography are disclosed herein. With minimal fabrication complexity, more uniform electric fields than conventional coplanar electrodes are produced. The methods disclosed are also more suitable for the construction of complex electrical sensor networks in microfluidic devices due to greater layout flexibility and provide improved sensitivity over conventional coplanar electrodes.
    Type: Application
    Filed: February 26, 2025
    Publication date: July 3, 2025
    Inventors: Ali Fatih SARIOGLU, Ruxiu LIU
  • Publication number: 20210394182
    Abstract: Embodiments of the microfluidic device may include of an array of microfluidic cell capture chambers, each functionalized with a different antibody to recognize a target antigen, and a network of code-multiplexed Coulter counters placed at strategic nodes across the device to quantify the fraction of cell population captured in each microfluidic chamber. For example, an apparatus may comprise a fluid inlet port divided into a plurality of separate microfluidic paths, each separate microfluidic path configured to transport a plurality of cells, the plurality of separate microfluidic paths, each comprising a plurality of microfluidic cell capture chambers, an outlet port to discharge a merged output of cells from the plurality of microfluidic cell capture chambers, and a plurality of sensors to detect cells passing into or out of a microfluidic cell capture chamber.
    Type: Application
    Filed: November 11, 2019
    Publication date: December 23, 2021
    Inventors: Ali Fatih SARIOGLU, Ruxiu Liu
  • Publication number: 20210394180
    Abstract: Systems and methods to integrate electrical sensors comprising parallel electrodes into microfluidic devices that are manufactured using soft lithography are disclosed herein. With minimal fabrication complexity, more uniform electric fields than conventional coplanar electrodes are produced. The methods disclosed are also more suitable for the construction of complex electrical sensor networks in microfluidic devices due to greater layout flexibility and provide improved sensitivity over conventional coplanar electrodes.
    Type: Application
    Filed: November 8, 2019
    Publication date: December 23, 2021
    Inventors: Ali Fatih SARIOGLU, Ruxiu LIU
  • Patent number: 11097273
    Abstract: The disclosed technology includes devices and methods for detecting rare cells in whole blood samples using a microfluidic device. Such devices include a housing with a microfluidic chamber having first and second microfluidic layers, each microfluidic layer having an array of microscale structure. Other disclosed devices also include a housing including a chemically functionalized hydrogel matrix and a pump connected to the housing. Disclosed methods include constructing, with an additive manufacturing device, a microfluidic device having a microfluidic chamber, removing, by a thermal release process, at least some of the sacrificial support material deposited by the additive manufacturing device, and chemically functionalizing at least a portion of the microfluidic chamber. Other disclosed methods include chemically functionalizing a hydrogel matrix and connecting the chemically functionalized hydrogel matrix to a pump.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: August 24, 2021
    Assignee: GEORGIA TECH RESEARCH CORPORATION
    Inventors: Ali Fatih Sarioglu, Chia-Heng Chu, Ruxiu Liu, Tevhide Ozkaya-Ahmadov
  • Publication number: 20190160464
    Abstract: The disclosed technology includes devices and methods for detecting rare cells in whole blood samples using a microfluidic device. Such devices include a housing with a microfluidic chamber having first and second microfluidic layers, each microfluidic layer having an array of microscale structure. Other disclosed devices also include a housing including a chemically functionalized hydrogel matrix and a pump connected to the housing. Disclosed methods include constructing, with an additive manufacturing device, a microfluidic device having a microfluidic chamber, removing, by a thermal release process, at least some of the sacrificial support material deposited by the additive manufacturing device, and chemically functionalizing at least a portion of the microfluidic chamber. Other disclosed methods include chemically functionalizing a hydrogel matrix and connecting the chemically functionalized hydrogel matrix to a pump.
    Type: Application
    Filed: June 28, 2017
    Publication date: May 30, 2019
    Inventors: Ali Fatih Sarioglu, Chia-Heng Chu, Ruxiu Liu, Tevhide Ozkaya-Ahmadov