Patents by Inventor Ruyun Ji

Ruyun Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080318949
    Abstract: The invention discloses a series of pyrazolopyrimidinone derivatives, which have the following chemical structure, their preparation methods and use, It has been proved by pharmacological experiment that the said pyrazolopyrimidinone derivatives have high inhibitory activity against PDE5, and parts of them have a much stronger potency against PDE5 than against PDE6. Most of the compounds show low toxicity. The pyrazolopyrimidinone derivatives can be used in clinics for the palliative or curative treatment of symptoms or diseases relating to cardiovascular system, urinary system, especially for the palliative or curative treatment of erectile dysfunction.
    Type: Application
    Filed: November 16, 2006
    Publication date: December 25, 2008
    Applicants: Topharman Shanghai Co., Ltd, Shanghai Institute of Materia Medica
    Inventors: Guanghui Tian, Shunan Lai, Zhen Wang, Yi Zhu, Xinjian Chen, Yurong Ji, Jinfeng Zhang, Weixi Jin, Heping Lv, Jinping Liu, Wei Wang, Ruyun Ji, Jingshan Shen
  • Patent number: 7456205
    Abstract: The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2 represents a hydrogen atom, a C1-6 alkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: November 25, 2008
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Yushe Yang, Lei Tang, Ruyun Ji, Kaixian Chen
  • Publication number: 20060178405
    Abstract: The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2 represents a hydrogen atom, a C1-6 alkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus.
    Type: Application
    Filed: February 26, 2003
    Publication date: August 10, 2006
    Inventors: Yushe Yang, Lei Tang, Ruyun Ji, Kaixian Chen
  • Publication number: 20060154970
    Abstract: The present invention provides alanines compounds of formula (I) or their salts: In the formula (I), the configuration of ?-Carbon atom of alanine is R or S; R1 is hydrogen, unsubstituted or substituted C1-6alkyl, unsubstituted or substituted aryl or aromatic heterocyclic group; R2 is hydrogen or unsubstituted or substituted C1-6 alkyl. The present invention also provides two methods of preparing these compounds or their salts, and their use in preparing anti II type diabetic medicine.
    Type: Application
    Filed: January 28, 2003
    Publication date: July 13, 2006
    Inventors: Yushe Yang, Lei Tang, Ruyun Ji, Kaixian Chen