Abstract: Methods and systems for breaking down an intravascular lesion. An illustrative method may comprise advancing a catheter through the vasculature to a target location. The catheter may a catheter shaft, an expandable member secured to a distal portion of the catheter shaft, and one or more ultrasound transducers. The method may further comprise activating the ultrasound transducer to emit an ultrasound field directed towards the target location.

Abstract: The present disclosure generally relates to medical devices and methods for navigating a catheter shaft into the body of a subject during an intracoronary or other medical procedure and controlling the distal end of the catheter shaft. The present disclosure includes the use of an introducer positioning device that may be used in combination with an introducer. The introducer positioning device when used in combination with an introducer allows a catheter shaft to be inserted therethrough and into the introducer shaft located in the introducer where a distal end of the catheter shaft is aligned with the distal end of the introducer shaft.

Abstract: A catheter has a body including a proximal region, a neck region, and a distal region. A shaping wire is disposed within the distal region to predispose it into at least a partial loop, which may have a fixed or variable radius of curvature. The shaping wire includes a distal portion having a circular transverse cross-sectional shape and a proximal portion having a non-circular (e.g., rectangular) transverse cross-sectional shape. The proximal portion of the shaping wire can have a width-to-thickness ratio of at least about 4, such as about 4.67. A transition portion can promote a gradual transition from the circular to the non-circular transverse cross-sectional shape, for example by increasing a width of the shaping wire by about 0.001? and/or by decreasing a thickness of the shaping wire by about 0.001? for every about 0.004? in length through the transition portion.

Abstract: Stent delivery systems and methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an inner member having a stent receiving region, a stent disposed along the stent receiving region, a deployment sheath axially slidable relative to the inner member, the deployment sheath having a proximal end region, a handle coupled to the deployment sheath, a rod coupled to the handle, the rod having a distal end region, a proximal end region and a first threaded portion extending from the distal end region to the proximal end region and a coupling member configured to couple the rod to the deployment sheath, the coupling member having an engagement portion. Additionally, the first threaded portion of the rod is designed to engage the engagement portion of coupling member and rotation of the rod is designed to translate the coupling member along the rod.

Abstract: Stent delivery systems and methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an inner member having a stent receiving region, a stent disposed along the stent receiving region, a deployment sheath axially slidable relative to the inner member, the deployment sheath having a proximal end region, a handle coupled to the deployment sheath, a rod coupled to the handle, the rod having a distal end region, a proximal end region and a first threaded portion extending from the distal end region to the proximal end region and a coupling member configured to couple the rod to the deployment sheath, the coupling member having an engagement portion. Additionally, the first threaded portion of the rod is designed to engage the engagement portion of coupling member and rotation of the rod is designed to translate the coupling member along the rod.

Abstract: Stent delivery systems and methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an inner member having a stent receiving region, a stent disposed along the stent receiving region, a deployment sheath axially slidable relative to the inner member, the deployment sheath having a proximal end region, a handle coupled to the deployment sheath, a rod coupled to the handle, the rod having a distal end region, a proximal end region and a first threaded portion extending from the distal end region to the proximal end region and a coupling member configured to couple the rod to the deployment sheath, the coupling member having an engagement portion. Additionally, the first threaded portion of the rod is designed to engage the engagement portion of coupling member and rotation of the rod is designed to translate the coupling member along the rod.

Abstract: The present disclosure generally relates to medical devices and methods for navigating a catheter shaft into the body of a subject during an intracoronary or other medical procedure and controlling the distal end of the catheter shaft. The present disclosure includes the use of an introducer positioning device that may be used in combination with an introducer. The introducer positioning device when used in combination with an introducer allows a catheter shaft to be inserted therethrough and into the introducer shaft located in the introducer where a distal end of the catheter shaft is aligned with the distal end of the introducer shaft.

Abstract: Disclosed herein is a catheter tip sized and configured to fit onto a distal end of a catheter shaft, the catheter shaft having a shaft outer diameter. The catheter tip includes a base, a tip having an arcuate shape, an outer surface extending from the base to the tip along a longitudinal axis, the outer surface having a diameter at the base that is substantially equal to the shaft outer diameter, and an inner surface extending from the base, wherein the inner surface defines a first region having a first diameter and a second region having a second diameter, wherein the second diameter is less than the first diameter, and wherein the second region is distal of the first region and configured to receive at least one component extending beyond the distal end of the catheter shaft.

Abstract: A catheter has a body including a proximal region, a neck region, and a distal region. A shaping wire is disposed within the distal region to predispose it into at least a partial loop, which may have a fixed or variable radius of curvature. The shaping wire includes a distal portion having a circular transverse cross-sectional shape and a proximal portion having a non-circular (e.g., rectangular) transverse cross-sectional shape. The proximal portion of the shaping wire can have a width-to-thickness ratio of at least about 4, such as about 4.67. A transition portion can promote a gradual transition from the circular to the non-circular transverse cross-sectional shape, for example by increasing a width of the shaping wire by about 0.001? and/or by decreasing a thickness of the shaping wire by about 0.001? for every about 0.004? in length through the transition portion.

Abstract: Disclosed herein is a method for determining a security classification for data that includes generating a classification signature for data based on a semantic interpretation of the data. The classification signature is associated with a security classification for the data. The method also includes comparing the generated classification signature to a predetermined classification signature associated with the security classification. Further, the method includes verifying the generated classification signature matches the predetermined classification signature.

Abstract: Disclosed herein is a method for determining a security classification for data that includes generating a classification signature for data based on a semantic interpretation of the data. The classification signature is associated with a security classification for the data. The method also includes comparing the generated classification signature to a predetermined classification signature associated with the security classification. Further, the method includes verifying the generated classification signature matches the predetermined classification signature.

Abstract: A method for managing job candidate information is provided. The method is performed by a computing device coupled to a database. The method includes receiving, by the computing device, job candidate information, performing semantic analysis on at least a first portion of the job candidate information, generating a prompt for additional information based on the semantic analysis, combining the additional information with the job candidate information into a master candidate profile, and storing the master candidate profile in the database.

Abstract: An isolation device includes an upper portion, a lower portion, and an isolation area. At least one of the upper and lower portions is constructed with a flexible shielding material. The isolation device may also include a conduit having one opening in the isolation area and another opening outside the isolation area.