Abstract: An orthopedic stabilization device is provided having a first button and a suture. The first button includes a base portion and a locking loop extending from a distal surface thereof, and a locking member slidably receiving the locking loop. At least a portion of the suture extends through the locking loop superior the locking member in the axial direction and at least a portion of the suture extends through the locking loop inferior the locking member in the axial direction such that a portion of said suture is frictionally retainable between said locking member and said locking loop when the suture is tensioned. The device may include a second button with the suture disposed between the first and second buttons such that the suture may be held in tension therebetween.

Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Embodiments of systems and methods are disclosed for inspecting features formed within and/or on a semiconductor substrate. More specifically, the present disclosure provides various embodiments of systems and methods to automatically adjust one or more parameters (or camera settings) used by a camera system to capture a stack of images of a feature formed within and/or on a semiconductor substrate before the images are processed to generate a three-dimensional (3D) reconstruction of the feature. In some embodiments, the disclosed systems and methods may filter the images included within the stack of images used for 3D reconstruction and dynamically determine when the camera system has captured enough images for 3D reconstruction of the feature. In doing so, the disclosed systems and methods may provide a more complete and accurate 3D reconstruction of the feature, while improving throughput of the wafer inspection process.

Abstract: Embodiments of the present application provide technologies related to adaptive surgeon-specific instrumentation, unique preparatory tools and procedures for bone resection and implant devices, and systems for selection of implantation preparatory tools for implantation procedures. The embodiments described herein may, for example, be utilized in connection with knee arthroplasty procedures.

Abstract: There are provided various embodiments of medical instruments to perform knee surgery. In one embodiment a finned platform for mounting a cutting block is provided. The finned platform can be used on either a femur or tibia to allow for the proper cuts when performing a knee surgery. In another embodiment, a tibial trial is shown having a fin. The fin is useful to reinforce the bone to reduce the risk of fracture during bone preparation. In another embodiment, a reamer is provided having a plurality of cutting flutes. It may be desirable to utilize a guide with the reamer to allow the reamer to cut a non-circular portion of the tibial bone. In yet another embodiment, a plurality of fixation pegs are provided on the tibial implant to allow for easy removal of such implant if a revision surgery becomes necessary.

Abstract: A method for optimizing a knee arthroplasty surgical procedure includes receiving pre-operative data comprising (i) anatomical measurements of the patient, (ii) soft tissue measurements of the patient's anatomy, and (iii) implant parameters identifying an implant to be used in the knee arthroplasty surgical procedure. An equation set is selected from a plurality of pre-generated equation sets based on the pre-operative data. During the knee arthroplasty surgical procedure, patient-specific kinetic and kinematic response values are generated and displayed using an optimization process. The optimization process includes collecting intraoperative data from one or more surgical tools of a computer-assisted surgical system, and using the intraoperative data and the pre-operative data to solve the equation set, thereby yielding the patient-specific kinetic and kinematic response values. A visualization is then provided of the patient-specific kinetic and kinematic response values on the displays.

Abstract: The present disclosure allows for more controlled modification of the input data to a Rapid Manufacturing Technologies (RMT) machinery to compensate for systematic error of the manufacturing process, such as directional build discrepancies, by performing the opposite effect to the input data. The modification is achieved with minimal unwanted distortions introduced to other portions of the structure to be built by decoupling the global scaling effects on the whole structure from the desired local effects on certain portions.

Abstract: Embodiments of the present application provide technologies related to adaptive surgeon-specific instrumentation, unique preparatory tools and procedures for bone resection and implant devices, and systems for selection of implantation preparatory tools for implantation procedures. The embodiments described herein may, for example, be utilized in connection with knee arthroplasty procedures.

Abstract: Alignment precision technology, in which a system accesses image data of a bone to which a reference marker array is fixed. The system generates a three-dimensional representation of the bone and the reference markers, defines a coordinate system for the three-dimensional representation, and determines locations of the reference markers relative to the coordinate system. The system accesses intra-operative image data that includes the bone and a mobile marker array that is attached to an instrument used in a surgical procedure. The system co-registers the intra-operative image data with the three-dimensional representation by matching the reference markers included in the intra-operative image data to the locations of the reference markers. The system determines locations of the mobile markers in the co-registered image and determines a three-dimensional spatial position and orientation of the instrument relative to the bone.

Abstract: A method for optimizing a knee arthroplasty surgical procedure includes receiving pre-operative data comprising (i) anatomical measurements of the patient, (ii) soft tissue measurements of the patient's anatomy, and (iii) implant parameters identifying an implant to be used in the knee arthroplasty surgical procedure. An equation set is selected from a plurality of pre-generated equation sets based on the pre-operative data. During the knee arthroplasty surgical procedure, patient-specific kinetic and kinematic response values are generated and displayed using an optimization process. The optimization process includes collecting intraoperative data from one or more surgical tools of a computer-assisted surgical system, and using the intraoperative data and the pre-operative data to solve the equation set, thereby yielding the patient-specific kinetic and kinematic response values. A visualization is then provided of the patient-specific kinetic and kinematic response values on the displays.

Abstract: Patient specific implant technology, in which an outline representation of a portion of an outer surface of a periphery of a bone volume is determined and the outline representation is used in operations related to implant matching. In addition, an instrument may be made to match a perimeter shape of a Patient Specific Knee Implant with features for locating holes in a distal femur such that posts or lugs in a femoral implant locate the femoral implant centered medial-laterally within an acceptable degree of precision to prevent overhang of either the side of the femoral implant over the perimeter of the distal femur bone resections. Further, a two-dimensional outline representation may be segmented into segments that correspond to resection cuts used in fitting an implant on a portion of a bone and operations related to implant matching may be performed based on the segments.

Abstract: A method of generating a custom three-dimensional (3D) model of a patient bone from one or more 2D images is disclosed. The method includes obtaining a 2D image of a bone, optionally of a joint, and identifying a 3D bone template for a candidate or representative bone from a pre-aligned library of representative bones. The method further includes repositioning one or more views of the 3D model or 2D images (e.g., with respect to rotation angle or caudal angle). In an iterative process, another 3D bone model for another candidate bone can be identified based on the repositioning until an accuracy threshold is satisfied. When the accuracy threshold is satisfied, surface region(s) of the current 3D bone model can then be modified to generate the resulting 3D model for the patient bone. The process can then be repeated for other bone(s) associated with the joint of the patient.

Abstract: A method for creating a patient-specific surgical plan includes receiving one or more pre-operative images of a patient having one or more infirmities affecting one or more anatomical joints. three-dimensional anatomical model of the one or more anatomical joints is created based on the one or more pre-operative images. One or more transfer functions and the three-dimensional anatomical model are used to identify a patient-specific implantation geometry that corrects the one or more infirmities. The transfer functions model performance of the one or more anatomical joints as a function of anatomical geometry and anatomical implantation features. surgical plan comprising the patient-specific implantation geometry may then be displayed.

Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: There are provided various embodiments of medical instruments to perform knee surgery. In one embodiment a finned platform for mounting a cutting block is provided. The finned platform can be used on either a femur or tibia to allow for the proper cuts when performing a knee surgery. In another embodiment, a tibial trial is shown having a fin. The fin is useful to reinforce the bone to reduce the risk of fracture during bone preparation. In another embodiment, a reamer is provided having a plurality of cutting flutes. It may be desirable to utilize a guide with the reamer to allow the reamer to cut a non-circular portion of the tibial bone. In yet another embodiment, a plurality of fixation pegs are provided on the tibial implant to allow for easy removal of such implant if a revision surgery becomes necessary.

Abstract: A method for creating a patient-specific surgical plan includes receiving one or more pre-operative images of a patient having one or more infirmities affecting one or more anatomical joints, three-dimensional anatomical model of the one or more anatomical joints is created based on the one or more pre-operative images. One or more transfer functions and the three-dimensional anatomical model are used to identify a patient-specific implantation geometry that corrects the one or more infirmities. The transfer functions model performance of the one or more anatomical joints as a function of anatomical geometry and anatomical implantation features, surgical plan comprising the patient-specific implantation geometry may then be displayed.

Abstract: A method for creating a patient-specific surgical plan includes receiving one or more pre-operative images of a patient having one or more infirmities affecting one or more anatomical joints. three-dimensional anatomical model of the one or more anatomical joints is created based on the one or more pre-operative images. One or more transfer functions and the three-dimensional anatomical model are used to identify a patient-specific implantation geometry that corrects the one or more infirmities. The transfer functions model performance of the one or more anatomical joints as a function of anatomical geometry and anatomical implantation features. surgical plan comprising the patient-specific implantation geometry may then be displayed.

Abstract: Alignment precision technology, in which a system accesses image data of a bone to which a reference marker array is fixed. The system generates a three-dimensional representation of the bone and the reference markers, defines a coordinate system for the three-dimensional representation, and determines locations of the reference markers relative to the coordinate system. The system accesses intra-operative image data that includes the bone and a mobile marker array that is attached to an instrument used in a surgical procedure. The system co-registers the intra-operative image data with the three-dimensional representation by matching the reference markers included in the intra-operative image data to the locations of the reference markers. The system determines locations of the mobile markers in the co-registered image and determines a three-dimensional spatial position and orientation of the instrument relative to the bone.

Abstract: Alignment precision technology, in which a system accesses image data of a bone to which a reference marker array is fixed. The system generates a three-dimensional representation of the bone and the reference markers, defines a coordinate system for the three-dimensional representation, and determines locations of the reference markers relative to the coordinate system. The system accesses intra-operative image data that includes the bone and a mobile marker array that is attached to an instrument used in a surgical procedure. The system co-registers the intra-operative image data with the three-dimensional representation by matching the reference markers included in the intra-operative image data to the locations of the reference markers. The system determines locations of the mobile markers in the co-registered image and determines a three-dimensional spatial position and orientation of the instrument relative to the bone.

Abstract: Systems and methods for optimizing parameters of an orthopaedic procedure for a particular patient, including parameters relating to the anatomic and biomechanic fit of an implant or implant system implanted into the patient's joint. These systems and methods may utilize patient-specific information gathered pre-operatively in conjunction with optimization algorithms to determine an optimal implant design and an optimal position and orientation for implantation of the implant into the particular patient's joint.