Abstract: A system for delivering a puncture system to puncture through a wall of a patient's blood vessel includes: a proximal catheter including a proximal lumen configured to accommodate both a primary navigation guide wire and the puncture system; a puncture system exit port in communication with the proximal lumen, wherein the puncture system exit port is configured to receive the puncture system, such that a portion of the puncture system passes through the puncture system exit port and exits the system; and a distal catheter including a distal lumen in communication with the proximal lumen, wherein the distal lumen is configured to accept the primary navigation guide wire and reject the puncture system, such that the primary navigation guide wire is able to enter the distal lumen and the puncture system is not able to enter the distal lumen.

Abstract: A system for delivering a puncture system to puncture through a wall of a patient's blood vessel includes: a proximal catheter including a proximal lumen configured to accommodate both a primary navigation guide wire and the puncture system; a puncture system exit port in communication with the proximal lumen, wherein the puncture system exit port is configured to receive the puncture system, such that a portion of the puncture system passes through the puncture system exit port and exits the system; and a distal catheter including a distal lumen in communication with the proximal lumen, wherein the distal lumen is configured to accept the primary navigation guide wire and reject the puncture system, such that the primary navigation guide wire is able to enter the distal lumen and the puncture system is not able to enter the distal lumen.

Abstract: In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.

Abstract: In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.

Abstract: A catheter system for implanting a lead for cardiac conduction system is provided. The catheter system includes a catheter having an orifice extending from a distal end of the catheter to a proximal end of the catheter for implanting the lead, and a probe extending through the catheter. The probe includes a conductive wire covered with an insulation layer. A distal end of the wire is exposed from the insulation layer. The distal end of the wire includes a wire electrode configured to conduct pacing prior to implanting the lead.

Abstract: According to embodiments, a cerebrospinal fluid (CSF) shunt includes: an inlet configured to receive CSF from a spinal intradural space in a patient; a shunt body with a sidewall and a lumen within the sidewall, wherein the shunt body is configured to extend through an interstitial space and a vein wall, wherein the lumen is in fluid communication with the inlet; and a regulator outside of the lumen, wherein the regulator is configured to regulate a flow of the CSF from the inlet by passing a regulated portion of the CSF from the lumen and into a venous system of the patient.

Abstract: A method including: introducing a shunt into a vascular system, wherein the shunt includes an inlet aperture in an inlet region and an outlet aperture in an outlet region; positioning the inlet region into an epidural or intervertebral vein; with a stylet, puncturing a wall of the epidural or intervertebral vein, traversing an interstitial space, and puncturing a thecal sac, wherein the stylet includes a wire extending through the shunt; moving the shunt to cause the inlet region to extend through a wall of the epidural or intervertebral vein; moving the shunt to cause the inlet region to extend into an interstitial space; and moving the shunt to cause the inlet region to extend through the thecal sac, such that the inlet region is positioned in an intradural space, and such that the outlet region is positioned in a venous pathway.

Abstract: A shunt delivery system includes: a stylet configured to puncture a vein wall, interstitial tissue, and a dura; a dilator including a transverse hollow interior region extending to an aperture in a distal region, the dilator configured to receive the stylet in the hollow interior region and out through the aperture in the distal region, the dilator configured to pass through tissues punctured by the stylet, including the vein wall, the interstitial tissue, and the dura; and a transdural catheter including a hollow interior region configured to receive the stylet, the transdural catheter configured to traverse the tissues dilated by the dilator, including the vein wall, the interstitial tissue, and the dura, such that a distal tip of the transdural catheter is configured to be located in a thecal sac of the patient.

Abstract: A lead for cardiac conduction system includes a proximal end, a lead body extending from the proximal end, and a distal end extending from the lead body. The lead body includes a non-conductive spacer. The distal end includes a helix electrode distal to the spacer. The lead further includes a ring electrode proximal to the spacer and surrounding a portion of the lead body. The helix electrode includes a core disposed within a helical space of the helix electrode. Another lead for cardiac conduction system includes a proximal end, a lead body extending from the proximal end, and a distal end extending from the lead body. The distal end includes a first helix electrode extending from the lead body and a second helix electrode extending from the lead body. A tip of the first helix electrode is distal to a tip of the second helix electrode.

Abstract: A shunt delivery system includes: a stylet configured to puncture a vein wall, interstitial tissue, and a dura; a dilator including a transverse hollow interior region extending to an aperture in a distal region, the dilator configured to receive the stylet in the hollow interior region and out through the aperture in the distal region, the dilator configured to pass through tissues punctured by the stylet, including the vein wall, the interstitial tissue, and the dura; and a transdural catheter including a hollow interior region configured to receive the stylet, the transdural catheter configured to traverse the tissues dilated by the dilator, including the vein wall, the interstitial tissue, and the dura, such that a distal tip of the transdural catheter is configured to be located in a thecal sac of the patient.

Abstract: According to embodiments, a cerebrospinal fluid (CSF) shunt includes: an inlet configured to receive CSF from a spinal intradural space in a patient; a shunt body with a sidewall and a lumen within the sidewall, wherein the shunt body is configured to extend through an interstitial space and a vein wall, wherein the lumen is in fluid communication with the inlet; and a regulator outside of the lumen, wherein the regulator is configured to regulate a flow of the CSF from the inlet by passing a regulated portion of the CSF from the lumen and into a venous system of the patient.

Abstract: Aspects of the present disclosure are directed to an implantable medical device including a housing containing components therein configured for delivering neurostimulation therapy, and an anchoring feature included with the housing. The implantable medical device also includes a lead having an electrode. In one aspect, the implantable medical device may include a guidewire passageway configured to allow the lead of implantable medical device to be introduced over a guidewire.

Abstract: Aspects of the present disclosure are directed to an implantable medical device including a housing containing components therein configured for delivering neurostimulation therapy, and an anchoring feature included with the housing. The implantable medical device also includes a lead having an electrode. In one aspect, the implantable medical device may include a guidewire passageway configured to allow the lead of implantable medical device to be introduced over a guidewire.

Abstract: A method including: introducing a shunt into a vascular system, wherein the shunt includes an inlet aperture in an inlet region and an outlet aperture in an outlet region; positioning the inlet region into an epidural or intervertebral vein; with a stylet, puncturing a wall of the epidural or intervertebral vein, traversing an interstitial space, and puncturing a thecal sac, wherein the stylet includes a wire extending through the shunt; moving the shunt to cause the inlet region to extend through a wall of the epidural or intervertebral vein; moving the shunt to cause the inlet region to extend into an interstitial space; and moving the shunt to cause the inlet region to extend through the thecal sac, such that the inlet region is positioned in an intradural space, and such that the outlet region is positioned in a venous pathway.

Abstract: A lead distal tip for a pacemaker includes a lead body including an insulated wire having a diameter of 2 French or less. The small size and flexibility of the lead distal tip and lead body reduce penetration and dislodgement risk for the lead distal tip. The lead distal tip can be delivered using a delivery catheter engaging with features on the lead distal tip to allow for the guidance and securement of the lead distal tip, despite its small and flexible nature. The attachment of the lead distal tip to heart tissue can be achieved by extending a linear member and/or a helical member from an end of the lead distal tip using features provided on the delivery catheter.

Abstract: Leadless pacemakers and methods of implanting the same are provided for a cardiac conduction system. A leadless pacemaker includes an implantable housing including a mounting interface, an electronic circuitry and a power source received by the implantable housing, and an electrode system connected to the electronic circuitry via the mounting interface. The electrode system includes electrodes configured to insert into a septum and having a length to reach pathways of the cardiac conduction system.

Abstract: A lead for a cardiac conduction system. The lead includes a lead body; a distal end including a first electrode configured to be inserted into a portion of a ventricular septum; a second electrode coupled to the lead body; a fixation element configured to fix the lead to the portion of the ventricular septum; and a proximal end. The lead further includes a shocking coil coupled to the lead body and spaced away from the second electrode.

Abstract: A lead for cardiac conduction system includes a proximal end, a lead body extending from the proximal end, and a distal end extending from the lead body. The lead body includes a non-conductive spacer. The distal end includes a helix electrode distal to the spacer. The lead further includes a ring electrode proximal to the spacer and surrounding a portion of the lead body. The helix electrode includes a core disposed within a helical space of the helix electrode. Another lead for cardiac conduction system includes a proximal end, a lead body extending from the proximal end, and a distal end extending from the lead body. The distal end includes a first helix electrode extending from the lead body and a second helix electrode extending from the lead body. A tip of the first helix electrode is distal to a tip of the second helix electrode.

Abstract: Aspects of the present disclosure are directed to an implantable medical device including a housing containing components therein configured for delivering neurostimulation therapy, and an anchoring feature included with the housing. The implantable medical device also includes a lead having an electrode. In one aspect, the implantable medical device may include a guidewire passageway configured to allow the lead of implantable medical device to be introduced over a guidewire.

Abstract: Aspects of the present disclosure are directed to an implantable medical device including a housing containing components therein configured for delivering neurostimulation therapy, and an anchoring feature included with the housing. The implantable medical device also includes a lead having an electrode. In one aspect, the implantable medical device may include a guidewire passageway configured to allow the lead of implantable medical device to be introduced over a guidewire.