Abstract: Certain embodiments are directed to methods for loading a liposome-containing alginate microsphere with an agent when the liposome-containing microsphere has been formed prior to loading of the liposome.

Abstract: Certain embodiments are directed to compositions comprising and method for producing alginate microspheres that contain liposomes encapsulating a variety of useful substances. Substances of note that can be encapsulated in liposomes and loaded alginate microspheres include radiotherapeutics (e.g., rhenium-188), radiolabels (e.g., technetium-99m), chemotherapeutics (doxorubicin), magnetic particles (e.g., 10 m iron nanoparticles), and radio-opaque material (e.g., iodine contrast).