Patents by Inventor RYAN BOKAN
RYAN BOKAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11666242Abstract: An example method includes applying a localization signal to a source electrode positioned within a conductive volume and a ground electrode at a known location. Electrical activity is sensed at a plurality of sensor electrodes distributed across an outer surface of the conductive volume. The locations of each of the sensor electrodes and the location of the ground electrode being stored in memory as part of geometry data. The electrical activity sensed at each of the sensor electrodes is stored in the memory as electrical measurement data. The method also includes computing a location of the source electrode by minimizing a difference between respective pairs of source voltages determined for the plurality of sensor electrodes. The source voltage for each of the sensor electrodes is determined based on the electrical measurement data and the geometry data.Type: GrantFiled: February 11, 2020Date of Patent: June 6, 2023Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Ping Jia, Qingguo Zeng, Charulatha Ramanathan, Ryan Bokan
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Patent number: 11131536Abstract: This disclosure relates to localization and tracking of an object. As one example, measurement data can be stored in memory to represent measured electrical signals at each of a plurality of known measurement locations in a given coordinate system in response to an applied signal at an unknown location in the given coordinate system. A dipole model cost function has parameters representing a dipole location and moment corresponding to the applied signal. A boundary condition can be imposed on the dipole model cost function. The unknown location in the given coordinate system, corresponding to the dipole location, can then be determined based on the stored measurement data and the dipole model cost function with the boundary condition imposed thereon.Type: GrantFiled: May 17, 2019Date of Patent: September 28, 2021Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qingguo Zeng, Ping Jia, Charulatha Ramanathan, Lijun Yu, Jeff Burrell, Brian George, Qing Lou, Ryan Bokan, Soniya Bhojwani
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Patent number: 10729345Abstract: For example, one or more non-transitory computer-readable media includes executable instructions to perform a method. The method includes defining a plurality of spatial regions distributed across a geometric surface. At least one wave front that propagates across the geometric surface is detected based on electrical data representing electrophysiological signals for each of a plurality of nodes distributed on the geometric surface over at least one time interval. An indication of conduction velocity of the wave front is determined for at least one spatial region of the plurality of spatial regions during the time interval based on a duration that the wave front resides within the at least one spatial region. Slow conduction activity is identified for the at least one spatial region based on comparing the indication of conduction velocity relative to a threshold. Conduction data is stored in memory to represent each slow conduction event.Type: GrantFiled: May 4, 2018Date of Patent: August 4, 2020Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qing Lou, Jeffrey B. Adair, Qingguo Zeng, Ping Jia, Ryan Bokan, Connor Edel, Rahsean Ellis, Brian P. George, Raja Ghanem, Timothy G. Laske
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Publication number: 20200170540Abstract: An example method includes applying a localization signal to a source electrode positioned within a conductive volume and a ground electrode at a known location. Electrical activity is sensed at a plurality of sensor electrodes distributed across an outer surface of the conductive volume. The locations of each of the sensor electrodes and the location of the ground electrode being stored in memory as part of geometry data. The electrical activity sensed at each of the sensor electrodes is stored in the memory as electrical measurement data. The method also includes computing a location of the source electrode by minimizing a difference between respective pairs of source voltages determined for the plurality of sensor electrodes. The source voltage for each of the sensor electrodes is determined based on the electrical measurement data and the geometry data.Type: ApplicationFiled: February 11, 2020Publication date: June 4, 2020Inventors: PING JIA, QINGGUO ZEN, CHARULATHA RAMANATHAN, RYAN BOKAN
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Patent number: 10568540Abstract: An example method includes applying a localization signal to a source electrode positioned within a conductive volume and a ground electrode at a known location. Electrical activity is sensed at a plurality of sensor electrodes distributed across an outer surface of the conductive volume. The locations of each of the sensor electrodes and the location of the ground electrode being stored in memory as part of geometry data. The electrical activity sensed at each of the sensor electrodes is stored in the memory as electrical measurement data. The method also includes computing a location of the source electrode by minimizing a difference between respective pairs of source voltages determined for the plurality of sensor electrodes. The source voltage for each of the sensor electrodes is determined based on the electrical measurement data and the geometry data.Type: GrantFiled: September 28, 2015Date of Patent: February 25, 2020Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Ping Jia, Qingguo Zeng, Charulatha Ramanathan, Ryan Bokan
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Publication number: 20190336023Abstract: For example, one or more non-transitory computer-readable media includes executable instructions to perform a method. The method includes defining a plurality of spatial regions distributed across a geometric surface. At least one wave front that propagates across the geometric surface is detected based on electrical data representing electrophysiological signals for each of a plurality of nodes distributed on the geometric surface over at least one time interval. An indication of conduction velocity of the wave front is determined for at least one spatial region of the plurality of spatial regions during the time interval based on a duration that the wave front resides within the at least one spatial region. Slow conduction activity is identified for the at least one spatial region based on comparing the indication of conduction velocity relative to a threshold. Conduction data is stored in memory to represent each slow conduction event.Type: ApplicationFiled: May 4, 2018Publication date: November 7, 2019Inventors: QING LOU, JEFFREY B. ADAIR, QINGGUO ZENG, PING JIA, RYAN BOKAN, CONNOR EDEL, RAHSEAN ELLIS, BRIAN P. GEORGE, RAJA GHANEM, TIMOTHY G. LASKE
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Patent number: 10426401Abstract: An example method includes receiving monitoring data representing one or more substantially real time electrical signals based on measurements from one or more respective electrodes. The method also includes selecting at least one signal of interest (SOI) from the monitoring data, each selected SOI being associated with a respective anatomical location and storing SOI data in memory corresponding to each selected SOI. The method also includes quantifying changes between signal characteristics of real time signals acquired for one or more respective anatomical locations and the at least one SOI that is associated with each of the respective anatomical locations. An output can be generated based on the quantifying to characterize spatially local signal changes with respect to each of the respective anatomical locations.Type: GrantFiled: August 28, 2015Date of Patent: October 1, 2019Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Ryan Bokan, Charulatha Ramanathan, Ping Jia, Meredith E. Stone
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Publication number: 20190271531Abstract: This disclosure relates to localization and tracking of an object. As one example, measurement data can be stored in memory to represent measured electrical signals at each of a plurality of known measurement locations in a given coordinate system in response to an applied signal at an unknown location in the given coordinate system. A dipole model cost function has parameters representing a dipole location and moment corresponding to the applied signal. A boundary condition can be imposed on the dipole model cost function. The unknown location in the given coordinate system, corresponding to the dipole location, can then be determined based on the stored measurement data and the dipole model cost function with the boundary condition imposed thereon.Type: ApplicationFiled: May 17, 2019Publication date: September 5, 2019Inventors: QINGGUO ZENG, PING JIA, CHARULATHA RAMANATHAN, LIJUN YU, JEFF BURRELL, BRIAN GEORGE, QING LOU, RYAN BOKAN, SONIYA BHOJWANI
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Patent number: 10323922Abstract: This disclosure relates to localization and tracking of an object. As one example, measurement data can be stored in memory to represent measured electrical signals at each of a plurality of known measurement locations in a given coordinate system in response to an applied signal at an unknown location in the given coordinate system. A dipole model cost function has parameters representing a dipole location and moment corresponding to the applied signal. A boundary condition can be imposed on the dipole model cost function. The unknown location in the given coordinate system, corresponding to the dipole location, can then be determined based on the stored measurement data and the dipole model cost function with the boundary condition imposed thereon.Type: GrantFiled: August 31, 2015Date of Patent: June 18, 2019Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qingguo Zeng, Ping Jia, Charulatha Ramanathan, Lijun Yu, Jeff Burrell, Brian George, Qing Lou, Ryan Bokan, Soniya Bhojwani
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Patent number: 10194982Abstract: A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.Type: GrantFiled: August 2, 2016Date of Patent: February 5, 2019Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Rémi Dubois, Brian P. George, Charulatha Ramanathan, Qingguo Zeng, Maria Strom, Venkatesh Vasudevan, Ryan Bokan, Ping Jia
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Patent number: 10117594Abstract: Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.Type: GrantFiled: August 18, 2016Date of Patent: November 6, 2018Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Qingguo Zeng, Ping Jia, Ryan Bokan, Brian P. George, Charulatha Ramanathan, Venkatesh Vasudevan, Maria Strom
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Patent number: 10076260Abstract: A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.Type: GrantFiled: September 21, 2017Date of Patent: September 18, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Ryan Bokan, Charulatha Ramanathan, Ping Jia, Maria Strom, Qingguo Zeng
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Patent number: 10004413Abstract: A method includes storing baseline data representing at least one local or global electrical characteristics for at least a portion of a region of interest (ROI) of a patient's anatomical structure. The baseline data is determined based on electrical measurement data obtained during at least one first measurement interval. The method also includes storing in memory other data representing the at least one local or global electrical characteristics for the at least a portion of the ROI based on electrical measurement data obtained during at least one subsequent measurement interval. The method also includes evaluating the baseline data relative to the other data to determine a change in the at least one local or global electrical characteristics. The method also includes generating an output based on the evaluating to provide an indication of progress or success associated with the applying the treatment.Type: GrantFiled: September 19, 2016Date of Patent: June 26, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Ryan Bokan, Charulatha Ramanathan, Ping Jia, Maria Strom
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Patent number: 9974462Abstract: A system includes an input to receive at least one electrophysiological signal representing cardiac electrical activity measured from a body surface of a patient. The system also includes a signal processor to analyze the at least one electrophysiological signal and compute a score having a value to indicate a likelihood of arrhythmogenic activity, the score being computed as a function of at least two of cycle length, amplitude and polarity of the at least one signal.Type: GrantFiled: February 19, 2016Date of Patent: May 22, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Vivek Jayan, Ping Jia, Ryan Bokan, Charulatha Ramanathan, Qingguo Zeng, Torsten Konrad
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Patent number: 9977060Abstract: A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.Type: GrantFiled: September 19, 2016Date of Patent: May 22, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Brian P. George, Charulatha Ramanathan, Ping Jia, Qingguo Zeng, Venkatesh Vasudevan, Maria Strom, Ryan Bokan, Rémi Dubois
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Publication number: 20180042507Abstract: A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.Type: ApplicationFiled: September 21, 2017Publication date: February 15, 2018Inventors: RYAN BOKAN, CHARULATHA RAMANATHAN, PING JIA, MARIA STROM, QINGGUO ZENG
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Patent number: 9883813Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.Type: GrantFiled: August 18, 2016Date of Patent: February 6, 2018Assignee: Cardioinsight Technologies, Inc.Inventors: Qingguo Zeng, Rémi DuBois, Ping Jia, Ryan Bokan, Venkatesh Vasudevan, Charulatha Ramanathan, Maria Strom, Brian P. George
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Patent number: 9820666Abstract: A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.Type: GrantFiled: February 4, 2015Date of Patent: November 21, 2017Assignee: CARDIOINSIGHT TECHNOLOGIES, INC.Inventors: Ryan Bokan, Charulatha Ramanathan, Ping Jia, Maria Strom, Qingguo Zeng
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Patent number: 9737267Abstract: A method can include storing a plurality of data sets including values computed for each of a plurality of points for a given spatial region of tissue, the values in each of the data sets characterizing electrical information for each respective point of the plurality of points for a different time interval. The method can also include combining the values computed for each of a plurality of points in a first interval, corresponding to a first map, with the values for computed for each of the respective plurality of points in another interval and to normalize the combined values relative to a common scale. The method can also include generating a composite map for the given spatial region based on the combined values that are normalized.Type: GrantFiled: January 16, 2014Date of Patent: August 22, 2017Assignee: Cardioinsight Technologies, Inc.Inventors: Maria Strom, Qingguo Zeng, Remi Dubois, Ping Jia, Ryan Bokan, Venkatesh Vasudevan, Charulatha Ramanathan, Brian P. George
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Patent number: 9668664Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.Type: GrantFiled: January 16, 2014Date of Patent: June 6, 2017Assignee: Cardioinsight Technologies, Inc.Inventors: Qingguo Zeng, Remi Dubois, Ping Jia, Ryan Bokan, Venkatesh Vasudevan, Charulatha Ramanathan, Maria Strom, Brian P. George