Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: A system may include a first computing system that may include at least one processor. The at least one processor may receive a request for identification information associated with a user of the first computing device, such that the request is received from a second computing device. The at least one processor may then receive information regarding an entity associated with the second computing device, retrieve data comprising the identification information from a storage component, generate additional data comprising a portion of the identification information based on the information regarding the entity, and send the additional data to the second computing device.

Abstract: Systems and methods for avoiding illegal stopping zones are provided. In example embodiments, a networked system identifies a destination of a driver providing a transportation service to a user. The networked system monitors a user device of the driver, and infers, based on the monitoring, that the driver is planning to stop in an illegal stopping zone located a predetermined distance to the destination. The inference is based on device data such as accelerometer data or location data that is triangulated with known or derived illegal stopping zones. In response, the networked system causes presentation of a notification on a user interface of the device of the driver. The notification provides an indication of the illegal stopping zone. In some embodiments, the notification also provides an alternative stopping location determined by the networked system.

Abstract: A self-sealing container is formed from a blank comprising panels and end flaps connected along fold lines with the panels and the end flaps being foldable along the fold lines to form the container. The container includes a securing feature that seals the container in a closed position, with the securing feature providing a visual indication of opening if the container is opened from the closed position. After the container is opened, the securing feature provides a closure feature that allows the container to be closed.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A self-sealing container is formed from a blank comprising panels and end flaps connected along fold lines with the panels and the end flaps being foldable along the fold lines to form the container. The container includes a securing feature that seals the container in a closed position, with the securing feature providing a visual indication of opening if the container is opened from the closed position. After the container is opened, the securing feature provides a closure feature that allows the container to be closed.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A self-sealing container is formed from a blank comprising panels and end flaps connected along fold lines with the panels and the end flaps being foldable along the fold lines to form the container. The container includes a securing feature that seals the container in a closed position, with the securing feature providing a visual indication of opening if the container is opened from the closed position. After the container is opened, the securing feature provides a closure feature that allows the container to be closed.

Abstract: A piston arrangement comprising: a piston; a rotatable element, rotatable about an axis, having a first engagement profile; and a mechanism comprising: a first connecting element connected to the piston; a second connecting element pivotable about a fixed point and pivotally connected to the first connecting element; and a second engagement profile coupled to the first and/or second connecting element, configured to mechanically engage and disengage with the first engagement profile of the rotatable element.

Abstract: A piston arrangement includes a piston movable within a cylinder in reciprocating motion along a piston axis, a rack movable with the piston, a sector gear configured to engage and disengage the rack and rotatable around a sector gear axis, a track adapted to rotate relative to the cylinder around a track axis of rotation, the piston being coupled to the track. The sector gear and the track are coupled in rotation. The track may have a shape such that the movement of the piston coupled to the track is substantially non simple harmonic. Also, an internal combustion engine comprising the piston arrangement.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A self-sealing container is formed from a blank comprising panels and end flaps connected along fold lines with the panels and the end flaps being foldable along the fold lines to form the container. The container includes a securing feature that seals the container in a closed position, with the securing feature providing a visual indication of opening if the container is opened from the closed position. After the container is opened, the securing feature provides a closure feature that allows the container to be closed.

Abstract: A self-sealing container is formed from a blank comprising panels and end flaps connected along fold lines with the panels and the end flaps being foldable along the fold lines to form the container. The container includes a securing feature that seals the container in a closed position, with the securing feature providing a visual indication of opening if the container is opened from the closed position. After the container is opened, the securing feature provides a closure feature that allows the container to be closed.

Abstract: A securable clip includes a first elongated rectangular portion and a second elongated rectangular portion connected along a common edge. The clip includes at least one locking peg, at least one receiving hole configured to receive the at least one locking peg, and a frangible portion. The frangible portion provides a visual indication that the clip has been opened. The releasing of the locking peg prevents the clip from being reclosed, reused, or sealed again.

Abstract: A self-sealing container is formed from a blank comprising panels and end flaps connected along fold lines with the panels and the end flaps being foldable along the fold lines to form the container. The container includes a securing feature that seals the container in a closed position, with the securing feature providing a visual indication of opening if the container is opened from the closed position. After the container is opened, the securing feature provides a closure feature that allows the container to be closed.

Abstract: Systems and methods for avoiding illegal stopping zones are provided. In example embodiments, a networked system identifies a destination of a driver providing a transportation service to a user. The networked system monitors a user device of the driver, and infers, based on the monitoring, that the driver is planning to stop in an illegal stopping zone located a predetermined distance to the destination. The inference is based on device data such as accelerometer data or location data that is triangulated with known or derived illegal stopping zones. In response, the networked system causes presentation of a notification on a user interface of the device of the driver. The notification provides an indication of the illegal stopping zone. In some embodiments, the notification also provides an alternative stopping location determined by the networked system.