Patents by Inventor Ryan Bremer

Ryan Bremer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20090286782
    Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of Fms protein kinase or Kit protein kinase.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 19, 2009
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Jiazhong Zhang, Marika Nespi, Hanna Cho
  • PDE4B inhibitors
    Patent number: 7605168
    Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: October 20, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Sam Gillette, Hanna Cho, Marika Nespi, Shumeye Mamo, Chao Zhang, Dean R. Artis, Byunghun Lee, Rebecca Zuckerman
  • PPAR active compounds
    Patent number: 7531568
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: May 12, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Jack Lin, Dean R. Artis, Prabha N. Ibrahim, Chao Zhang, Rebecca Zuckerman, Ryan Bremer, Shenghua Shi, Byunghun Lee
  • Compounds modulating c-fms and/or c-kit activity and uses therefor
    Publication number: 20090076046
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: November 21, 2007
    Publication date: March 19, 2009
    Inventors: Jiazhong Zhang, Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Guoxian Wu, Hongyao Zhu, Marika Nespi, Chao Zhang
  • Compounds and methods for development of Ret modulators
    Patent number: 7504509
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: March 17, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20080221148
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: December 20, 2007
    Publication date: September 11, 2008
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Chao Zhang, Jiazhong Zhang, Klaus-Peter Hirth, Guoxian Wu, Hongyao Zhu
  • Compounds and methods for development of Ret modulators
    Publication number: 20070049615
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: December 17, 2004
    Publication date: March 1, 2007
    Inventors: Prabha Ibrahim, Dean Artis, Ryan Bremer, Gaston Habets, Clarence Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • Compounds modulating c-kit and c-fms activity and uses therefor
    Publication number: 20070032519
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
    Type: Application
    Filed: May 16, 2006
    Publication date: February 8, 2007
    Inventors: Chao Zhang, Jiazhong Zhang, Prabha Ibrahim, Clarence Hurt, Rebecca Zuckerman, Dean Artis, Ryan Bremer, Wayne Spevak, Guoxian Wu, Hongyao Zhu
  • PPAR active compounds
    Publication number: 20060116416
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: November 29, 2005
    Publication date: June 1, 2006
    Inventors: Jack Lin, Dean Artis, Prabha Ibrahim, Chao Zhang, Rebecca Zuckerman, Ryan Bremer, Shenghua Shi, Byunghun Lee
  • PDE4B inhibitors
    Publication number: 20060100218
    Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: September 2, 2005
    Publication date: May 11, 2006
    Inventors: Prabha Ibrahim, Ryan Bremer, Sam Gillette, Hanna Cho, Marika Nespi, Shumeye Mamo, Chao Zhang, Dean Artis, Byunghun Lee, Rebecca Zuckerman
  • Molecular scaffolds for kinase ligand development
    Publication number: 20050164300
    Abstract: Molecular scaffolds for compounds active on protein kinases are described, along with methods for using such scaffolds for kinase ligand development. The use of kinase structural information, exemplified with PIM-1 crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate particular kinases.
    Type: Application
    Filed: September 15, 2004
    Publication date: July 28, 2005
    Inventors: Dean Artis, Ryan Bremer, Samuel Gillette, Clarence Hurt, Prabha Ibrahim, Rebecca Zuckerman
  • Crystal structure of PIM-1 kinase
    Publication number: 20040142864
    Abstract: A crystal structure of PIM-1 is described that was determined by X-ray crystallography. The use of PIM-1 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PIM-1 and other PIM kinases.
    Type: Application
    Filed: September 16, 2003
    Publication date: July 22, 2004
    Applicant: Plexxikon, Inc.
    Inventors: Ryan Bremer, Prabha Ibrahim, Abhinav Kumar, Valsan Mandiyan, Michael V. Milburn