Patents by Inventor Ryan C. Griswold
Ryan C. Griswold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220057305Abstract: Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample.Type: ApplicationFiled: August 3, 2021Publication date: February 24, 2022Inventors: Frank B. Myers, III, Wei Hsuan Ho, Debkishore Mitra, John Robert Waldeisen, Ivan Krastev Dimov, Ryan C. Griswold, Bruce Richardson
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Patent number: 11125661Abstract: Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample.Type: GrantFiled: March 14, 2017Date of Patent: September 21, 2021Assignee: Lucira Health. Inc.Inventors: Frank B. Myers, III, Wei Hsuan Ho, Debkishore Mitra, John Robert Waldeisen, Ivan Krastev Dimov, Ryan C. Griswold, Bruce Richardson
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Publication number: 20190194765Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: February 27, 2019Publication date: June 27, 2019Applicant: GeneWeave Biosciences, Inc.Inventors: Diego Ariel REY, Shaunak ROY, Leonardo Maestri TEIXEIRA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE, Werner FREI
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Publication number: 20190094114Abstract: Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample.Type: ApplicationFiled: March 14, 2017Publication date: March 28, 2019Inventors: Frank B. Myers, III, Wei Hsuan Ho, Debkishore Mitra, John Robert Waldeisen, Ivan Krastev Dimov, Ryan C. Griswold, Bruce Richardson
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Patent number: 10240212Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: December 22, 2016Date of Patent: March 26, 2019Assignee: GeneWeave Biosciences, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee, Werner Frei
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Patent number: 10125386Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: GrantFiled: November 30, 2016Date of Patent: November 13, 2018Assignee: GeneWeave Biosciences, Inc.Inventors: Nikol De Forest, Werner Frei, Diego Rey, Shaunak Roy, Soni Shukla, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee
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Publication number: 20170233783Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: ApplicationFiled: November 30, 2016Publication date: August 17, 2017Applicant: GeneWeave Biosciences, Inc.Inventors: Nikol DE FOREST, Werner FREI, Diego Rey, Shaunak Roy, Soni SHUKLA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. Yee
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Publication number: 20170152576Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: December 22, 2016Publication date: June 1, 2017Applicant: GeneWeave Biosciences, Inc.Inventors: Diego Ariel REY, Shaunak ROY, Leonardo Maestri TEIXEIRA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE
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Patent number: 9546391Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: September 8, 2014Date of Patent: January 17, 2017Assignee: GeneWeave Biosciences, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Werner Frei, Bruce J. Richardson, Ryan C. Griswold, Damian S. Matthews, Kenneth G. Olson, Victor H. Yee
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Patent number: 9540675Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: GrantFiled: February 9, 2015Date of Patent: January 10, 2017Assignee: GeneWeave Biosciences, Inc.Inventors: Nikol De Forest, Werner Frei, Diego Rey, Shaunak Roy, Soni Shukla, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee
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Patent number: 9481903Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: March 13, 2013Date of Patent: November 1, 2016Assignee: Roche Molecular Systems, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor Yee
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Patent number: 9133497Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: February 2, 2015Date of Patent: September 15, 2015Assignee: GeneWeave Biosciences, Inc.Inventors: Werner Frei, Diego Ariel Rey, Shaunak Roy, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Rick V. Stellmacher
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Publication number: 20150218613Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: ApplicationFiled: February 9, 2015Publication date: August 6, 2015Applicant: GeneWeave Biosciences, Inc.Inventors: Nikol DE FOREST, Werner FREI, Diego REY, Shaunak ROY, Soni SHUKLA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE
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Publication number: 20150148261Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: February 2, 2015Publication date: May 28, 2015Applicant: GENEWEAVE BIOSCIENCES, INC.Inventors: Werner FREI, Diego Ariel REY, Shaunak ROY, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Rick V. STELLMACHER
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Publication number: 20150132795Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: September 8, 2014Publication date: May 14, 2015Applicant: GeneWeave Biosciences, Inc.Inventors: Ryan C. GRISWOLD, Bruce J. RICHARDSON, Rick V. STELLMACHER, Victor H. YEE
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Publication number: 20140273180Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: October 8, 2013Publication date: September 18, 2014Applicant: GENEWEAVE BIOSCIENCES, INC.Inventors: Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Rick V. STELLMACHER, Victor H. YEE
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Patent number: 8829473Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: October 8, 2013Date of Patent: September 9, 2014Assignee: GeneWeave Biosciences, Inc.Inventors: Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Rick V. Stellmacher, Victor H. Yee