Abstract: In a plug an abandon environment with casing and a tubular string running through the casing a tool is placed at a desired location for a severing of the inner tubular. A first set of blades is extended from a housing to cut radially until the inner tubular is severed. A second set of blades are then extended for axial milling with a reach limit of the outside wall of the severed tubular at a location between upsets. As the axial milling reaches an upset, the second set of blades is allowed to retract and a third set with a longer reach is extended to axially mill the upset. Thereafter the third set of blades is allowed to retract and the second set is extended to continue axial milling. The second and third sets of blades can be reversed so that initial axial milling can be at the upset rather than between the upsets followed by milling between the upsets with the shorter reach blades.

Abstract: A tubular cleaning tool can be delivered through tubing and then hydraulically or mechanically actuated to rotate blades about respective pivot location into approximately a 45 degree orientation for commencement of tool rotation and cleaning a larger tubular that is below. Each of the blades has a cantilevered distal end that further features at least one articulated link. The outer periphery of the articulated distal segment has hard facing to enhance the cleaning effect and to reduce blade wear. The remainder of the blade outer surface can also have hard facing for similar reasons. The distal segment can be biased toward the surrounding tubular when the blades extend to put the segment in the needed orientation for cleaning.

Abstract: In a plug an abandon environment with casing and a tubular string running through the casing a tool is placed at a desired location for a severing of the inner tubular. A first set of blades is extended from a housing to cut radially until the inner tubular is severed. A second set of blades are then extended for axial milling with a reach limit of the outside wall of the severed tubular at a location between upsets. As the axial milling reaches an upset, the second set of blades is allowed to retract and a third set with a longer reach is extended to axially mill the upset. Thereafter the third set of blades is allowed to retract and the second set is extended to continue axial milling. The second and third sets of blades can be reversed so that initial axial milling can be at the upset rather than between the upsets followed by milling between the upsets with the shorter reach blades.

Abstract: A tubular cleaning tool can be delivered through tubing and then hydraulically or mechanically actuated to rotate blades about respective pivot location into approximately a 45 degree orientation for commencement of tool rotation and cleaning a larger tubular that is below. Each of the blades has a cantilevered distal end that further features at least one articulated link. The outer periphery of the articulated distal segment has hard facing to enhance the cleaning effect and to reduce blade wear. The remainder of the blade outer surface can also have hard facing for similar reasons. The distal segment can be biased toward the surrounding tubular when the blades extend to put the segment in the needed orientation for cleaning.

Abstract: The invention relates to certain amino-pyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).

Abstract: The invention relates to certain amino-pyrimidine compounds that inhibit IKK epsilon and/or TBK1, methods of making such compounds, pharmaceutical compositions comprising such compounds, and the use of these compounds in treating a variety of diseases and disorders.

Abstract: Disclosed are compounds, which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also exhibit an increased duration of action.

Abstract: Disclosed are compounds, which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also exhibit an increased duration of action.

Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.

Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.