Abstract: The disclosure relates to methods and kits for detecting, quantifying, or both, phosphorylated tau (p-tau) in a biological sample. The disclosure further provides methods for detecting brain-associated tau polypeptide, a brain injury or a neurodegenerative disease in a subject, determining the eligibility of individuals for participation in clinical trials for brain injury and/or neurodegenerative disease treatments, distinguishing between individuals with brain injury and/or neurodegenerative disease and without brain injury and/or neurodegenerative disease, and monitoring response to treatment of the same.

Abstract: A mobile ordering system for a restaurant configured to request processing of an order made by a customer with a mobile device when the customer enters a predetermined geographic region associated with the restaurant as determined by a server configured to process global positioning satellite (“GPS”) data received from the mobile device. A user associated with the restaurant uses the mobile restaurant ordering system to define the predetermined geographic region. The server may be configured to dynamically alter the predefined geographic region associated with the restaurant based on certain factors associated with the restaurant, the order, and/or the customer.

Abstract: Systems and methods for ordering systems and, more specifically, to a proximity based ordering system are disclosed herein. A computer-implemented method, according to some implementations of the present disclosure, includes receiving, in a computer system, a selection of an order by a user of a user device, the order including a selection of a restaurant and at least one item to purchase from the restaurant, determining, by the computer system, if the user is within a geofence defined in regard to the restaurant, upon determining that the user is not within the geofence, holding, by the computer system, the order from being prepared at the restaurant, and upon determining that the user is within the geofence, releasing, by the computer system, the order to be prepared at the restaurant.

Abstract: Systems and methods for ordering systems and, more specifically, to a proximity based ordering system are disclosed herein. A computer-implemented method, according to some implementations of the present disclosure, includes receiving, in a computer system, a selection of an order by a user of a user device, the order including a selection of a restaurant and at least one item to purchase from the restaurant, determining, by the computer system, if the user is within a geofence defined in regard to the restaurant, upon determining that the user is not within the geofence, holding, by the computer system, the order from being prepared at the restaurant, and upon determining that the user is within the geofence, releasing, by the computer system, the order to be prepared at the restaurant.

Abstract: Non-occlusive modeling catheters including a dilation device for expanding an endoprosthesis implanted in a vessel are disclosed. In an embodiment, a modeling catheter includes a device comprising a plurality of compliant wires braided in a double overlapping pattern and having a length spanning between a proximal end of the device and a distal end of the device, wherein the device is positioned in at least a portion of an endoprosthesis implanted in a vessel, wherein, when the device is in a relaxed state, a plurality of spaces are formed between the plurality of wires to allow fluid to move freely through the plurality of spaces, and wherein, when the device is in a dilated state, the plurality of wires are sufficiently designed to exert a radial force on the endoprosthesis while continually allowing the fluid to move freely through the plurality of spaces.

Abstract: Over-the-wire self-sizing, self-centering valvulotomes sufficiently designed to cut valves through a wide range of vein diameters and adjust to the internal diameter of a vein as the valvulotome is being drawn through the vessel, and methods of use thereof during certain medical procedures that involve splitting valves, are disclosed herein. In an embodiment, an over-the-wire valvulotome includes a catheter having a proximal end, a distal end, and a longitudinal axis therebetween, wherein a first portion of a plurality of cutting tools engage the catheter at the distal end, and wherein an actuation mechanism engages the catheter at the proximal end; a retainer for temporarily shielding a second portion of the plurality of cutting tools, wherein the second portion includes cutting blades; and a sheath slidably moveable over the plurality of cutting blades, wherein the catheter and the retainer have internal diameters configured for passing over a guidewire.

Abstract: Over-the-wire self-sizing, self-centering valvulotomes sufficiently designed to cut valves through a wide range of vein diameters and adjust to the internal diameter of a vein as the valvulotome is being drawn through the vessel, and methods of use thereof during certain medical procedures that involve splitting valves, are disclosed herein. In an embodiment, an over-the-wire valvulotome includes a catheter having a proximal end, a distal end, and a longitudinal axis therebetween, wherein a first portion of a plurality of cutting tools engage the catheter at the distal end, and wherein an actuation mechanism engages the catheter at the proximal end; a retainer for temporarily shielding a second portion of the plurality of cutting tools, wherein the second portion includes cutting blades; and a sheath slidably moveable over the plurality of cutting blades, wherein the catheter and the retainer have internal diameters configured for passing over a guidewire.

Abstract: Non-occlusive modeling catheters including a dilation device for expanding an endoprosthesis implanted in a vessel are disclosed. In an embodiment, a modeling catheter includes a device comprising a plurality of compliant wires braided in a double overlapping pattern and having a length spanning between a proximal end of the device and a distal end of the device, wherein the device is positioned in at least a portion of an endoprosthesis implanted in a vessel, wherein, when the device is in a relaxed state, a plurality of spaces are formed between the plurality of wires to allow fluid to move freely through the plurality of spaces, and wherein, when the device is in a dilated state, the plurality of wires are sufficiently designed to exert a radial force on the endoprosthesis while continually allowing the fluid to move freely through the plurality of spaces.