Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.

Abstract: Levers with fulcrums and other linkages can be structured to provide motion in many different structural formations by making adjustments to the parameters of a mechanism such as this invention. Mechanisms with multiple levers working together in coordination and moving a fraction of the full actuation allows machines to be built more efficiently. The levers can be connected to each other in multiple configurations which allow for these machines to be built and programmed from how the levers are connected to each other. This invention is modular so building complex actuators is a simple procedure. The machine can be used as a mechanical actuator or a projectile launcher or a programmable moving mechanism where the programming is built in the structure. By using levers, and simple energy mechanisms to power this invention, the overall efficiency of some processes can be increased.

Abstract: An apparatus and methods for installation of an offshore platform for supporting equipment installations is provided. The apparatus includes a platform configured to support offshore equipment supported by a structure such as a modular column assembly. The modular column assembly can be comprised of main barrel joint bundles.

Abstract: A method for ascertaining an emotional goal includes receiving, via an emotionally responsive computerized system having a user interface communicatively coupled to a networked user device including a processor device, user-input concerning a purpose of a user's interaction with a software interface. It can include registering input indicating a target person to whom the purpose of the user's interaction pertains and prompting the user to provide a root motivator comprising a root emotion or a root reason for the interaction. Some variations include generating a user-perceptible output and a set of user interface elements dependent on the root motivator along with obtaining the user's specific emotional goal with respect to the target person on the basis of user-inputs in response to a presentation of a sequence of user interface elements, to provide the user, via the software interface, a recommendation regarding a fulfillment of the specific emotional goal.

Abstract: A computer program component configured to collect configuration item data from information technology resources of an air-gapped network for an information technology configuration management database is provided. Configuration item data collected from the information technology resources of the air-gapped network is obtained using the provided computer program component, wherein the obtained configuration item data is physically transferred between a device within the air-gapped network and a device outside the air-gapped network at least in part via a portable physical storage medium, and the collected configuration item data has been reviewed and filtered within the air-gapped network prior to being physically transferred via the portable physical storage medium. The obtained configuration item data is imported to the information technology configuration management database outside the air-gapped network.

Abstract: In one embodiment of the present invention, a fixation device including a sleeve member including an interior and an exterior surface along a length defined between a first end and a second end, and at least two openings positioned along the length and extending from the interior and through the exterior surface; and a filament including a first free end and a second free end and a length therebetween, the filament positioned relative to the sleeve member such that the free ends extend from the sleeve member at the first and second ends of the sleeve member, the filament being disposed inside the interior from the first end to a first opening, outside the sleeve member from the first opening to a second opening, and inside the interior from the second opening to the second end of the sleeve member.

Abstract: Methods and systems for separating an object, such as a lead, from formed tissue are provided. Specifically, a tissue slitting apparatus is configured to engage formed tissue at a slitting engagement point. While the object is subjected to a first traction force, the tissue slitting apparatus is caused to move further into the engaged tissue and slit the tissue past the point of engagement. The slitting apparatus causes the tissue to separate along an axial direction of the length of the formed tissue and releases at least some of the force containing the object. The slitting apparatus is supported by a distal end support device configured to lock onto the lead. While supported, a slitting element of the apparatus places fibers of the formed tissue under tension and performs a lifting cut operation. The methods and systems are well suited for use in cardiac pacing or defibrillator lead explant procedures.

Abstract: The present disclosure provides an adaptive energy storage operating system that is programmed or otherwise configured to operate and optimize various types of energy storage devices.

Abstract: A method of selecting building equipment for serving a building including determining one or more hard constraints and one or more soft constraints for the building equipment, determining a plurality of possible combinations of building equipment to serve the building, determining a first set of possible combinations that meet all of the hard constraints and all of the soft constraints, determining a second set of possible combinations that meet all of the hard constraints and do not meet all of the soft constraints, selecting a combination of building equipment to serve the building from the first set of possible combinations if the first set contains a possible combination, or selecting a combination of building equipment to serve the building from the second set of possible combinations if the first set contains no possible combinations, and serving the building using the selected combination of building equipment.

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.

Abstract: A central plant includes a plurality of subplants and circuitry. The circuitry is configured to obtain an expert model associated with a first subplant of the plurality of subplants. The expert model includes a map of values of independent variables to one or more dependent variables. The circuitry is also configured to receive input data indicating input values for the independent variables and estimate outputs values for the one or more dependent variables associated with the input variables by determining a spatial relationship between the input data and the expert model, reducing the expert model to a reduced model based on the spatial relationship, and performing an interpolation using the reduced model to generate the output values for the one or more dependent variables. The circuitry is also configured to initiate an automated action using the output values.

Abstract: A computer program component configured to collect configuration item data from information technology resources of an air-gapped network for an information technology configuration management database is provided. Configuration item data collected from the information technology resources of the air-gapped network is obtained using the provided computer program component, wherein the obtained configuration item data is physically transferred between a device within the air-gapped network and a device outside the air-gapped network at least in part via a portable physical storage medium, and the collected configuration item data has been reviewed and filtered within the air-gapped network prior to being physically transferred via the portable physical storage medium. The obtained configuration item data is imported to the information technology configuration management database outside the air-gapped network.

Abstract: The present disclosure provides an adaptive energy storage operating system that is programmed or otherwise configured to operate and optimize various types of energy storage devices.

Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.

Abstract: A motor vehicle according to an exemplary aspect of the present disclosure includes, among other things, a sensor, a headlamp, and a controller configured to adjust an aim of the headlamp based on a signal from the sensor. The controller is configured to account for a zero drift of the sensor. A method is also disclosed.

Abstract: A central plant includes a plurality of subplants including a chiller configured to output supply water at a supply water temperature, a sensor configured obtain a measurement of the supply water temperature, and a control system. The control system is configured to calculate an additional load factor based on the measurement of the supply water temperature and a supply water temperature setpoint, obtain an actual load for the chiller, calculate an effective load based on the additional load factor and the actual load, generate load allocations for the plurality of subplants based on the effective load, and control the plurality of subplants to operate in accordance with the load allocations.

Abstract: A vehicle is provided. The vehicle may include a detachable roof assembly that includes an upper B-pillar extending from a longitudinal roof rail that extends between a pair of transverse roof bows. The vehicle may also include a frame assembly. The frame assembly may include a lower B-pillar that extends from a rocker panel to a beltline of the vehicle. The lower B-pillar may include an upper end that defines a receptacle that may receive at least 50% of the upper B-pillar when the roof assembly is assembled to the frame assembly.

Abstract: A vehicle is provided. The vehicle may include a detachable roof assembly that includes an upper B-pillar extending from a longitudinal roof rail that extends between a pair of transverse roof bows. The vehicle may also include a frame assembly. The frame assembly may include a lower B-pillar that extends from a rocker panel to a beltline of the vehicle. The lower B-pillar may include an upper end that defines a receptacle that may receive at least 50% of the upper B-pillar when the roof assembly is assembled to the frame assembly.

Abstract: The present disclosure provides an adaptive energy storage operating system that is programmed or otherwise configured to operate and optimize various types of energy storage devices.

Abstract: The present disclosure provides an adaptive energy storage operating system that is programmed or otherwise configured to operate and optimize various types of energy storage devices.