Abstract: A vehicle includes a controller programmed to, responsive to receiving information for an appointment. The controller is further programmed to schedule a valet event using the information in anticipation for a valet mode associated with the appointment. The valet event includes one or more conditions. The controller is further programmed to responsive the one or more conditions being met, activate the valet mode to restrict at least one vehicle function without requiring a user authentication.

Abstract: A structural support assembly for a vehicle, the structural support assembly comprising a longitudinal frame member that extends parallel to a longitudinal centerline of the vehicle and has an inner rail wall and an outer rail wall, a cross-member operably coupled to the longitudinal frame member and extending substantially perpendicular to the longitudinal centerline, and an internal frame reinforcement member only operably coupled to the inner rail wall of the longitudinal frame member. The internal frame reinforcement member may be disposed proximate to an intersection of the cross-member and the longitudinal frame member.

Abstract: A vehicle includes a frame having a longitudinal rail and a structural member supported by the frame. The structural member includes a front bracket joined to the rail and having an arm that extends outwardly away from the rail. The structural member further includes a curved elongate member having a first end connected to an outer end of the arm and extending rearwardly therefrom to a second end that is spaced from the rail. A rear bracket of the structural member is connected to the rail and defines a slot that receives the second end of the curved elongate member therein. A width of the slot is wider than a width of the second end such that the second end can slide rearwardly within the slot.

Abstract: A vehicle includes a controller programmed to, responsive to receiving information for an appointment, schedule a valet event using the information in anticipation for a valet mode associated with the appointment, wherein the valet event includes one or more conditions, and responsive the one or more conditions being met, activate the valet mode to restrict at least one vehicle function without requiring a user authentication.

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.

Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.

Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.

Abstract: A motor vehicle according to an exemplary aspect of the present disclosure includes, among other things, a sensor, a headlamp, and a controller configured to adjust an aim of the headlamp based on a signal from the sensor. The controller is configured to account for a zero drift of the sensor. A method is also disclosed.

Abstract: A vehicle is provided. The vehicle may include a detachable roof assembly that includes an upper B-pillar extending from a longitudinal roof rail that extends between a pair of transverse roof bows. The vehicle may also include a frame assembly. The frame assembly may include a lower B-pillar that extends from a rocker panel to a beltline of the vehicle. The lower B-pillar may include an upper end that defines a receptacle that may receive at least 50% of the upper B-pillar when the roof assembly is assembled to the frame assembly.

Abstract: A vehicle is provided. The vehicle may include a detachable roof assembly that includes an upper B-pillar extending from a longitudinal roof rail that extends between a pair of transverse roof bows. The vehicle may also include a frame assembly. The frame assembly may include a lower B-pillar that extends from a rocker panel to a beltline of the vehicle. The lower B-pillar may include an upper end that defines a receptacle that may receive at least 50% of the upper B-pillar when the roof assembly is assembled to the frame assembly.

Abstract: A motor vehicle according to an exemplary aspect of the present disclosure includes, among other things, a sensor, a headlamp, and a controller configured to adjust an aim of the headlamp based on a signal from the sensor. The controller is configured to account for a zero drift of the sensor. A method is also disclosed.

Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.

Abstract: A vehicle locator system may include a sensor in communication with a lighting system, a wireless transceiver, an illumination assembly received within a housing, and a controller. The controller may be configured to command the illumination assembly to emit light according to a first pattern, responsive to a communication from a remote device received through the wireless transceiver. The communication may include a request to operate the illumination assembly in a vehicle locator mode, while a vehicle ignition is off.

Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.

Abstract: A vehicle includes a frame, a subframe, a powertrain, a steering gear, and a bracket. The subframe is fastened to the frame at a subframe attachment point, and the subframe is movable relative to the frame along a collision path in response to a frontal collision. The powertrain is attached to the subframe. The steering gear is coupled to the subframe and disposed in the collision path between the powertrain and the subframe attachment point. The bracket is attached to the powertrain and disposed in the collision path between the powertrain and the steering gear. The bracket is positioned to wedge the steering gear between the subframe and the frame during the frontal collision to deform the subframe at the subframe attachment point.

Abstract: A vehicle includes a frame, a subframe, a powertrain, a steering gear, and a bracket. The subframe is fastened to the frame at a subframe attachment point, and the subframe is movable relative to the frame along a collision path in response to a frontal collision. The powertrain is attached to the subframe. The steering gear is coupled to the subframe and disposed in the collision path between the powertrain and the subframe attachment point. The bracket is attached to the powertrain and disposed in the collision path between the powertrain and the steering gear. The bracket is positioned to wedge the steering gear between the subframe and the frame during the frontal collision to deform the subframe at the subframe attachment point.

Abstract: A vehicle includes a vehicle body that includes a rocker fixed to an underbody. The rocker and the under body at least in part define a front wheel well of the vehicle. A rim engagement member is cantilevered from the underbody and extends into the wheel well. The rim engagement member snags a rim of a front wheel of the vehicle and directs movement of a front wheel of the vehicle away from intrusion into a floor and/or dash of the vehicle.

Abstract: A vehicle includes a vehicle body that includes a rocker fixed to an underbody. The rocker and the under body at least in part define a front wheel well of the vehicle. A rim engagement member is cantilevered from the underbody and extends into the wheel well. The rim engagement member snags a rim of a front wheel of the vehicle and directs movement of a front wheel of the vehicle away from intrusion into a floor and/or dash of the vehicle.

Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.