Abstract: An embodiment of the system of the present invention generally comprises a mailpiece sorting apparatus which includes a feeder, an OCR scanner, a video scanner, a mailpiece transporter, a diverter and output module, compartments or bins for receiving sorted mailpieces, optical character recognition system for reading addressee information, an addressee database, a suspect database, and microprocessor based control system. In alternate embodiments of the present invention: the system is contained in a detection area and clean room and/or connection to an investigation entity. The system and method of integrates prediction of the presence of life harming material in mailpieces with mailpiece processing so as to help deter delays in incoming mail delivery caused by the presence of life harming material the suspected presence of life harming material and to protect the intended recipients from harm.