Patents by Inventor Ryan F. Workman
Ryan F. Workman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8846036Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.Type: GrantFiled: December 5, 2008Date of Patent: September 30, 2014Assignee: Abbott LaboratoriesInventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Robert N. Ziemann, Frank C. Grenier, Ryan F. Workman, Lowell Tyner
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Patent number: 8697365Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.Type: GrantFiled: March 24, 2011Date of Patent: April 15, 2014Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Patent number: 8541554Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.Type: GrantFiled: December 29, 2010Date of Patent: September 24, 2013Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Ryan F. Workman, Hina Syed, Salman Ali
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Patent number: 8440416Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.Type: GrantFiled: July 12, 2012Date of Patent: May 14, 2013Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Patent number: 8394606Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.Type: GrantFiled: November 4, 2009Date of Patent: March 12, 2013Assignee: Abbott LaboratoriesInventors: Salman Ali, Ryan M. Bonn, Frank C. Grenier, Tracey D. Rae, Kevin R. Rupprecht, Hina N. Syed, Bailin Tu, Joan D. Tyner, Ryan F. Workman
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Publication number: 20120288875Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.Type: ApplicationFiled: July 12, 2012Publication date: November 15, 2012Applicant: ABBOTT LABORATORIESInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Patent number: 8221986Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.Type: GrantFiled: June 25, 2009Date of Patent: July 17, 2012Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Publication number: 20110171662Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.Type: ApplicationFiled: March 24, 2011Publication date: July 14, 2011Applicant: ABBOTT LABORATORIESInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Publication number: 20110091997Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.Type: ApplicationFiled: December 29, 2010Publication date: April 21, 2011Applicant: ABBOTT LABORATORIESInventors: FRANK C. GRENIER, RYAN F. WORKMAN, HINA SYED, SALMAN ALI
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Patent number: 7914999Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.Type: GrantFiled: December 29, 2006Date of Patent: March 29, 2011Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Patent number: 7883855Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.Type: GrantFiled: July 21, 2006Date of Patent: February 8, 2011Assignee: Abbott LaboratoriesInventors: Frank C. Grenier, Ryan F. Workman, Hina Syed, Salman Ali
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Publication number: 20100227775Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.Type: ApplicationFiled: May 21, 2010Publication date: September 9, 2010Applicant: ABBOTT LABORATORIESInventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann
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Publication number: 20100116662Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.Type: ApplicationFiled: November 4, 2009Publication date: May 13, 2010Applicant: ABBOTT LABORATORIESInventors: Salman Ali, Ryan M. Bonn, Frank C. Grenier, Tracey D. Rae, Kevin R. Rupprecht, Hina N. Syed, Bailin Tu, Joan D. Tyner, Ryan F. Workman
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Publication number: 20090325193Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.Type: ApplicationFiled: June 25, 2009Publication date: December 31, 2009Applicant: ABBOTT LABORATORIESInventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Publication number: 20090269777Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.Type: ApplicationFiled: April 16, 2008Publication date: October 29, 2009Applicant: Abbott LaboratoriesInventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Ryan F. Workman, Robert N. Ziemann
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Publication number: 20090123946Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.Type: ApplicationFiled: December 5, 2008Publication date: May 14, 2009Applicant: ABBOTT LABORATORIESInventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann, Lowell J. Tyner
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Publication number: 20080160499Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.Type: ApplicationFiled: December 29, 2006Publication date: July 3, 2008Inventors: Frank C. Grenier, Ryan F. Workman, Hina N. Syed, Salman Ali
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Publication number: 20080020401Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.Type: ApplicationFiled: July 21, 2006Publication date: January 24, 2008Inventors: Frank C. Grenier, Ryan F. Workman, Hina Syed, Salman Ali