Abstract: An exemplary optical measurement system described herein includes a control circuit configured to output a global bias voltage and a module communicatively coupled to the control circuit. The module includes a light source configured to emit light directed at a target. The module further includes a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target. The module further includes a module control circuit configured to receive the global bias voltage and output a plurality of detector bias voltages based on the global bias voltage. The plurality of detector bias voltages include a respective detector bias voltage for each detector of the plurality of detectors.

Abstract: An exemplary system includes a photodetector configured to generate a photodetector output pulse when the photodetector detects a photon from a light pulse having a light pulse time period, a TDC configured to monitor for the occurrence of the photodetector output pulse during a measurement time window that is within and shorter in duration than the light pulse time period, a PLL circuit for the TDC, and a precision timing circuit connected to the PLL circuit and configured to adjust, based on at least one signal generated within the PLL circuit, a temporal position of the measurement time window within the light pulse time period.

Abstract: An illustrative optical measurement system includes a signal generator configured to generate a signal and a processing unit configured to direct the signal generator to apply the signal to a TDC included in the optical measurement system and generate, based on timestamp symbols recorded by the TDC in response to the signal, characterization data representative of a nonlinearity of the TDC.

Abstract: An illustrative optical measurement system may include a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target and a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, wherein a ratio of a total number of the detectors to a total number of the light sources is at least two to one.

Abstract: An exemplary system includes a first photodetector configured to detect a first photon via a first path from a light source and a second photodetector configured to detect a second photon via a second path. The system includes a control system configured to record a first time based on the first photodetector detecting the first photon, the first time including a delay between the first photodetector detecting the first photon and the control system receiving a photodetector output pulse from the first photodetector. The control system is configured to record a second time based on the second photodetector detecting the second photon, the second time including a delay between the second photodetector and the control system. The control system is configured to determine, based on the first and second time, an amount of time for the second photon to travel from the light source to the second photodetector.

Abstract: An exemplary system includes a photodetector configured to generate a plurality of photodetector output pulses over time as a plurality of light pulses are applied to and scattered by a target, a TPSF generation circuit configured to generate, based on the photodetector output pulses, a TPSF representative of a light pulse response of the target, and a control circuit configured to direct the TPSF generation circuit to selectively operate in different resolution modes.

Abstract: An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit. The processing unit is configured to measure a noise level of a photodetector included in the array of photodetectors and determine that the noise level meets a predetermined threshold. The processing unit is further configured to prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors.

Abstract: An exemplary optical measurement system includes a light source configured to emit light directed at a target. The optical measurement system further includes a photodetector configured to detect a photon of the light after the light is scattered by the target. The optical measurement system further includes a control circuit configured to receive a first input voltage that is a temperature-dependent voltage. The control circuit is further configured to receive a second input voltage that is a temperature-invariant voltage. The control circuit is further configured to output, based on a combination of the first input voltage and the second input voltage, a bias voltage for the photodetector, wherein the combination of the first and second input voltages is configured to cause the bias voltage to vary based on temperature.

Abstract: An exemplary system includes a light source and a control circuit configured to apply voltage having a first polarity to the light source for a first time period to provide a threshold charge for the light source to start an emission of a light pulse that is directed at a target within a body. The control circuit is further configured to apply voltage having a second polarity opposite the first polarity to the light source for a second time period subsequent to the first time period to discharge the light source to stop the emission of the light pulse.

Abstract: An exemplary system includes a processor, a wearable device comprising a plurality of slots, and a first module including a plurality of detectors and a module control circuit. The processor is configured to successively transmit, to each slot of the plurality of slots, a command to enable a respective module located in each slot. The processor is further configured to determine, based on an acknowledgment received from the module control circuit, that the first module is enabled and located in a first slot, and to successively transmit, based on the determining that the first module is enabled and located in the first slot, a plurality of detector address identifiers. The module control circuit is configured to successively place the plurality of detectors into an enumeration mode in which each detector of the plurality of detectors is assigned a different detector address identifier of the plurality of detector address identifiers.

Abstract: An exemplary system includes a PLL circuit and a precision timing circuit connected to the PLL circuit. The PLL circuit has a PLL feedback period defined by a reference clock and includes a voltage controlled oscillator configured to lock to the reference clock and having a plurality of stages configured to output a plurality of fine phase signals each having a different phase, and a feedback divider configured to be clocked by a single fine phase signal included in the plurality of fine phase signals and have a plurality of feedback divider states during the PLL feedback period. The precision timing circuit is configured to generate a timing pulse and set, based on a first combination of one of the fine phase signals and one of the feedback divider states, a temporal position of the timing pulse within the PLL feedback period.

Abstract: An exemplary optical measurement system includes a signal generator configured to generate a signal and a processing unit configured to direct the signal generator to apply the signal to a component within the optical measurement system, generate, based on a response of the component to the signal, characterization data representative of a timing uncertainty associated with the component, and perform, based on the characterization data, an action associated with the component.

Abstract: An illustrative system includes a wearable assembly configured to be worn by a user and comprising a first detector configured to detect a first set of photon arrival times and output a first signal representative of the first set of photon arrival times, and a second detector configured to detect a second set of photon arrival times and output a second signal representative of the second set of photon arrival times. The system further includes a processing unit configured to identify a first intensity change in the first signal, identify a second intensity change in the second signal, determine that the first and second intensity changes are time correlated, and determine, based on the determining that the first and second intensity changes are time correlated, that the first and second intensity changes are representative of a motion artifact caused by movement of the user.

Abstract: An illustrative optical measurement system includes a light source configured to emit, during a measurement session time period, a sequence of light pulses towards a target; a plurality of photodetectors configured to remain in an armed state during an entire duration of the measurement session time period, and detect, while in the armed state, photons of the light pulses after the light pulses are scattered by the target; and a plurality of time-to-digital converters (TDCs) comprising a different TDC for each photodetector of the plurality of photodetectors, the TDCs configured to record timestamp symbols representative of when the photons are detected by the photodetectors.

Abstract: Among the various aspects of the present disclosure is the provision of a methods and compositions for modulating IncRNAs and methods of treatment based on IncRNA expression.

Abstract: An exemplary wearable brain interface system includes a head-mountable component and a control system. The head-mountable component includes an array of photodetectors that includes a photodetector comprising a single-photon avalanche diode (SPAD) and a fast-gating circuit configured to arm and disarm the SPAD. The control system is for controlling a current drawn by the array of photodetectors.

Abstract: A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.

Abstract: A wearable module for use in an optical measurement system may include a first light source configured to emit a first light pulse in a first wavelength, a second light source configured to emit a second light pulse in a second wavelength that is different from the first wavelength, a light guide configured to guide the first light pulse and the second light pulse toward a target within a body of a user; an optical member configured to receive the first light pulse from the first light source and the second light pulse from the second light source and direct the first light pulse and the second light pulse to the light guide, and a housing that houses the first light source, the second light source, and the optical member.

Abstract: An optical measurement system includes a first light source configured to emit a first light pulse toward a target, a second light source configured to emit a second light pulse toward the target, a first detector, a second detector, and a processing unit. The processing unit is configured to determine a plurality of temporal distributions of photons included in the first light pulse and the second light pulse and detected by the first detector and the second detector after the photons are scattered by the target. The processing unit is further configured to determine, based on the plurality of temporal distributions, a distance between the first light source and the second detector.

Abstract: An optical measurement system includes a wearable module assembly configured to be worn on a body of a user. The wearable module assembly includes a plurality of wearable modules and a connecting assembly. Each wearable module includes a light source configured to emit a light pulse toward a target within the body of the user and a plurality of detectors configured to receive photons included in the light pulse after the photons are scattered by the target. The connecting assembly physically and flexibly connects the plurality of wearable modules such that the wearable module assembly is conformable to a three-dimensional (3D) surface of the body of the user when the wearable module assembly is worn on the body of the user.