Abstract: The present disclosure relates to glycan-modified nucleic acids, including short interfering RNA molecules. The glycan-modified nucleic acids include an oligosaccharide moiety that is bond to the nucleic acid and that contains a multiple antennary complex type N-glycan. The disclosure also relates to pharmaceutical compositions containing such glycan-modified nucleic acids, and methods for making and using such glycan-modified nucleic acids.

Abstract: Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease.

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae I-XXV, as set forth herein.

Abstract: The present disclosure relates to glyconucleic acids, such as glycoRNA and glycoDNA described herein. Provided are glycosylated ribonucleic acid (glycoRNA)-related methods and compositions.

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.

Abstract: Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease.

Abstract: An apparatus and method for using rotating shield brachytherapy (RSBT). In an aspect, the RSBT system and method can be used to maintain or increase tumor dose relative to conventional techniques with a dramatic reduction in radiation dose to the urethra, rectum, and bladder in the treatment of prostate cancer through placing partially shielded radiation sources away from sensitive tissues. In an aspect, the invention is an apparatus and method for the precise angular and linear positioning of multiple partially-shielded radiation sources in interstitial needles. In a further aspect, the invention comprises a monitoring and control apparatus for the precise and simultaneous angular positioning of multiple shield-containing catheters in the RBST system by measuring and correcting deviations between actual and desired catheter angular positions and depth in real time before and during treatment delivery.

Abstract: Disclosed is an apparatus for securely storing, labeling, and automatically dispensing a medication to a patient. The apparatus includes an interface for verifying the identity of the patient prior to the medicine being dispensed. The patient obtains the medication via a dispenser that is selectively rotatable between secure and dispensing sides. The disclosure further relates to an associated system and method for allowing a health care professional to remotely prescribe a medication that is subsequently dispensed by the apparatus.

Abstract: Systems and methods for low energy radiation x-ray radiation therapy system for use at a target within a cavity of a subject. In an aspect, the system uses an aperture shaping device used to shape the radiation beam from the low energy radiation source. In an aspect, the aperture shaping device includes a plurality of leaf assemblies which include leaves configured to form the aperture and engage the radiation beam. In an aspect, the present invention utilizes a geared mechanics approach to create an aperture using only one dial input. The design ensures that the field size of the collimator remains a constant shape as it is opened and closed. In an aspect, the overall size of the collimator may be scaled to accommodate various radiation therapy requirements.

Abstract: An apparatus and method for using rotating shield brachytherapy (RSBT). In an aspect, the RSBT system and method can be used to maintain or increase tumor dose relative to conventional techniques with a dramatic reduction in radiation dose to the urethra, rectum, and bladder in the treatment of prostate cancer through placing partially shielded radiation sources away from sensitive tissues. In an aspect, the invention is an apparatus and method for the precise angular and linear positioning of multiple partially-shielded radiation sources in interstitial needles. In a further aspect, the invention comprises a monitoring and control apparatus for the precise and simultaneous angular positioning of multiple shield-containing catheters in the RBST system by measuring and correcting deviations between actual and desired catheter angular positions and depth in real time before and during treatment delivery.

Abstract: In some aspects, the instant disclosure relates to methods of treating chronic graft versus host disease (cGVHD). In some embodiments, the method comprises administering to a subject in need thereof a EZH2 inhibitor, a Bcl6 inhibitor and/or BRD4 inhibitor. The present disclosure is based, at least in part, on the discovery that enhancer of zeste homolog 2 (EZH2) inhibitors, B-cell lymphoma 6 protein (Bcl6) inhibitors and/or bromodomain-containing protein 4 (BRD4) inhibitors can be used to treat chronic graft versus host disease (cGVHD).

Abstract: Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT). In an aspect, the catheter system can utilize paddle-based RSBT. Further provided are methods and systems for helical RSBT.

Abstract: Systems and methods for low energy radiation x-ray radiation therapy system for use at a target within a cavity of a subject. In an aspect, the system uses an aperture shaping device used to shape the radiation beam from the low energy radiation source. In an aspect, the aperture shaping device includes a plurality of leaf assemblies which include leaves configured to form the aperture and engage the radiation beam. In an aspect, the present invention utilizes a geared mechanics approach to create an aperture using only one dial input. The design ensures that the field size of the collimator remains a constant shape as it is opened and closed. In an aspect, the overall size of the collimator may be scaled to accommodate various radiation therapy requirements.

Abstract: Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease.

Abstract: A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.

Abstract: Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT). In an aspect, the catheter system can utilize paddle-based RSBT. Further provided are methods and systems for helical RSBT.

Abstract: The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.

Abstract: A spot scanning (SS) ion therapy system configured for dynamic trimming of an ion particle pencil beam to reduce the amount of the radiation dosage outside of a target boundary.

Abstract: Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT), In an aspect, I-RSBT needles can deliver dose distributions that can be non-radially symmetric about each needle, enabling reduced doses to sensitive normal tissues. Further provided are methods and systems for selecting an emission angle for use in S-RSBT and for sequencing the rotating shields. Further provided are methods and system for the multiple application of M-RSBT in a single setting.

Abstract: Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease.