Abstract: A system, methods and devices for automating inspection of a brake system on a railway vehicle, such as a freight car or train of a plurality of cars is provided. According to preferred embodiments, the system may be configured for use in conjunction with existing braking systems currently on railway vehicles, such as those on freight cars and other railway vehicles. The system, methods and devices comprise a wireless brake monitoring sensor that includes a radar unit or circuitry and directs a beam toward targets that designated as one or more brake assembly components or locations on the components to monitor a condition or position of a brake or brake component.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: The disclosure relates to compositions including STING inhibitors. Methods of treating subjects with a traumatic brain injury by administering STING inhibitors are also included.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: A computer-enabled system and method that collects and processes various data from mobile devices possessed by on-demand cargo delivery transportation drivers, along with other possible external data sources, and subsequently recognizes, classifies, stores, and delivers cargo delivery-related activity information of individual or multiple drivers to various consumers of the system, while also iteratively improving the system and method's cargo delivery activity classification accuracy over time.

Abstract: In implementations, a high-voltage power system may include circuitry and a cell-to-pack battery that is operatively connected to the circuitry. The cell-to-pack battery has: a cell arrangement including one or more cells, the cell arrangement configured to store energy for conversion into electrical energy for use in the high-voltage power system; a thermal management system having at least one of a first cooling plate arranged at a first side of the cell arrangement and a second cooling plate is arranged at a second side of the cell arrangement; and a modular open frame with which to secure the cell arrangement and the thermal management system, the modular open frame including a manifold for vent gas collection and an electrical box that houses a majority of electrical components for the battery pack, each of the manifold and the electrical box being connectible to the cell arrangement.

Abstract: A method of treating or preventing Alzheimer's disease or related dementias in patients previously infected with a respiratory virus such as SARS CoV2 is presented. Brain gene expression profiles of severe COVID-19 patients show increased expression of several innate immune response genes and genes implicated in Alzheimer's disease pathogenesis. The gene expression signature includes genes involved in inflammation, protein folding/trafficking, complement activation, calcium homeostasis, and amyloid/tau processing. The gene expression signature is correlated with tau pathology, ?-synuclein, and demyelination with neuroinflammation being increased in old versus young CoV-2 infected mice.

Abstract: A composition including a cannabinoid and an anti-cancer agent and methods of treating lung cancer using said composition.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: A system, methods and devices for automating inspection of a brake system on a railway vehicle, such as a freight car or train of a plurality of cars is provided. According to preferred embodiments, the system may be configured for use in conjunction with existing braking systems currently on railway vehicles, such as those on freight cars and other railway vehicles. The system, methods and devices comprise a wireless brake monitoring sensor that includes a radar unit or circuitry and directs a beam toward targets that designated as one or more brake assembly components or locations on the components to monitor a condition or position of a brake or brake component.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: A computer-enabled system and method that collects and processes various data from mobile devices possessed by on-demand (“ride-hailing”) transportation drivers, along with other possible external data sources, and subsequently recognizes, classifies, stores, and delivers ride-hailing-related activity information of individual or multiple drivers to various consumers of the system, while also iteratively improving the system and method's ride-hailing activity classification accuracy over time.

Abstract: The present disclosure provides novel gravitational flow assays for detecting an antigen in a biological sample using DNA-capture sequences. Specifically, gravitational flow assays and methods of detecting viruses, including coronaviruses, are provided.

Abstract: A frame assembly for inspection of pipeline girth weld, having a support frame releasably coupled to a mounting band that comprises of two clamshell halves. The clamshell halves are coupled via quick release coupling mechanisms. By removing one of the clamshells, or uncouple the two clamshells at one coupling point, the frame assembly permits a RTR scanner assembly to be laterally displaced along the length of the pipeline.

Abstract: A frame assembly for inspection of pipeline girth weld, having a support frame releasably coupled to a mounting band that comprises of two clamshell halves. The clamshell halves are coupled via quick release coupling mechanisms. By removing one of the clamshells, or uncouple the two clamshells at one coupling point, the frame assembly permits a RTR scanner assembly to be laterally displaced along the length of the pipeline.

Abstract: The invention relates to the methods to increase populations of cancer stem cells (CSCs), including human CSCs, using, for example, a FiSS™ (fiber-inspired smart scaffold) platform, a scaffold for cell culture comprising an electrospun mixture of poly(lactic-co-glycolic acid) (PLGA) and a block copolymer of polylactic acid (PLA) and monomethoxypolyethylene glycol (mPEG). As an example, we demonstrated that MCF-7 cells grown on FiSScsc developed into well-formed single-cell tumoroids (SCTs), showing a ˜3-fold increase in the cancer stem cell (CSC) population versus similar-passage cells grown as monolayers. This increase was further potentiated when the first-generation tumoroids were used to grow second- and third-generation tumoroids. Additionally, we scaled-up the cell culturing protocol from, for example, a 96-well plate to, for example, a 6-well plate, with no loss in the induction of CSCs.

Abstract: A pneumatic manifold with internal and external porting is machined in a specific sequence for pressurized and exhausting air control. Electro-pneumatic valves and or blocking plates are fastened and sealed to the positions of exterior porting. The electro-pneumatic valves complete the pneumatic circuit already machined in the manifold. Electro-pneumatic valves can be added or removed depending on the required functions. Other exterior ports on the manifold allow for but are not limited to connection of a pressure transducer, exterior pilot feeds, individual open/close speed controls, individual secondary slow down speed controls for open and close. The manifold allows the mounting of three electro-pneumatic valves wherein each valve controls a certain specific sequential function. When used with a compatible means of electronic control, the manifold can replace most pneumatic control devices driving a pneumatic actuator for the purpose of moving an access mechanism, such as a garage door.