Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A turbine shroud segment, e.g. for a gas turbine engine, which is coolable by a supply of cooling air, e.g. from a gas turbine engine compressor. The turbine shroud segment has a segment casing that has a radially outer surface and a radially inner surface. The segment casing houses a main plenum, a first layer of impingement chambers, a second layer of impingement chambers, and a plurality of effusion passages. The first layer of impingement chambers fluidly communicates with the main plenum via transfer passages that are formed in the segment casing. The second layer of impingement chambers fluidly communicates with the first layer of impingement chambers via impingement passages that are formed in the segment casing. The effusion passages run between impingement chamber core surface, which is a radially inner surface of an impingement chamber, and the radially inner surface of the segment casing.

Abstract: The present disclosure generally relates to capturing multiple types of data during execution of an application, the multiple types of data including data associated with messages published by nodes and metadata corresponding to execution of nodes. The multiple types of data are then stored with associated message identifiers to efficiently capture all data needed for playback. In some examples, such techniques allow for deterministic playback, even when nodes are concurrently operating on different compute systems.

Abstract: The present disclosure generally relates deploying an application. Some techniques described herein occur during compile time while executable code is being generated from source code. In one example, the executable code causes different operations in an application to be assigned to different compute systems such that particular operations are required to be executed on particular compute systems. The executable code may further include bridges that assist data being transmitted between different compute systems, the bridges generated during compile time. In another example, the executable code causes data to be sent to a recording service during execution of an application. The recording service, though not included in the source code before compile time, is configured to receive copies of data transmitted on a compute system including the recording service. The recording service may also be configured to receive metadata corresponding to operations executed on the compute system.