Abstract: A method of selecting components for a multivariate optical computing and analysis system to isolate a spectral region includes selecting a spectral region of interest; selecting a spectral element with a predetermined transmission characteristic to control a spectral range of an illumination source; illuminating a sample with the illumination source; and analyzing an optical frequency returned by the sample relative to the spectral region of interest.

Abstract: A method of real-time processing and monitoring comprises the steps of blending a material of interest (e.g., an active pharmaceutical material), with a secondary material, (e.g., an excipient), illuminating the blended materials with light, reflecting light carrying information about the blended materials through at least one multivariate optical element (148) and detecting said light with a first detector (152), detecting a deflected portion of the information carrying light with a second detector (156), and determining in real-time at least one selected property of the blended materials based on the detector outputs.

Abstract: Methods of selecting spectral elements and system components for a multivariate optical analysis system include providing spectral calibration data for a sample of interest; identifying a plurality of combinations of system components; modeling performance of a pilot system with one of the combinations of system components; determining optimal characteristics of the pilot system; and selecting optimal system components from among the combinations of system components.

Abstract: A method of arranging and utilizing a multivariate optical computing and analysis system includes transmitting a o first light from a light source; generating a second light by reflecting the first light from the sample; directing a portion of the second light with a beamsplitter; and arranging an optical filter mechanism in a normal incidence orientation to receive the portion of the second light, the optical filter mechanism being configured to optically filter data carried by the portion of the second light.

Abstract: A method of developing a multivariate optical element for an optical analysis system includes forming an optically absorptive spectral element having an optically absorptive material, the optically absorptive material being absorbing in a predetermined spectral region; and utilizing the optically absorptive spectral element in the optical analysis system.

Abstract: Multivariate optical analysis systems employ multivariate optical elements and utilize multivariate optical computing methods to determine information about a product carried by light reflected from or transmitted through the product.

Abstract: A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample

Abstract: Methods of assessing feasibility of a project include receiving a datum from a customer; designing an application specific system based on the datum; analyzing the datum; evaluating a set of input parameters to determine an applicability of the application specific system to a customer process; and providing feedback for the customer process with the application specific system.