Abstract: A system and a method are disclosed for receiving a request for a user to perform a plurality of activities with respect to a secure document, a given activity of the plurality activities being assigned based on a known parameter of the user. The system transmits the request to the user, and responsive to detecting an interaction with the request, determines that the known parameter has changed. The system responsively determines requirements for performing the plurality of activities based on a replacement parameter of the user, determines a replacement activity based on the requirements, and transmits a new request to the user, the new request replacing the given activity with the replacement activity.

Abstract: A method is provided for generating single-stranded DNA circles from a biological sample. The method comprises the steps of: treating the biological sample with an extractant to release nucleic acids, thereby forming a sample mixture; neutralizing the extractant; denaturing the released nucleic acids to generate single-stranded nucleic acids; and contacting the single-stranded nucleic acids with a ligase that is capable of template-independent, intramolecular ligation of single-stranded DNA to generate the single-stranded DNA circles. All the steps of the method are performed without any intermediate nucleic acid isolation or nucleic acid purification. The single-stranded DNA circles may be amplified and further analyzed. Also provided is a kit which comprises compositions for carrying out the novel methods.

Abstract: A passive modification device comprising an elongated body extending along a first axis made of a shape memory alloy with a threshold contraction along the first axis at a threshold temperature. The modification device further comprises a passageway extending along a second axis shaped to surround a conduit line extending along the second axis. The modification device further includes a first modifying structure on a first portion of the passageway and a second modifying structure on a second portion of the passageway opposite the first modifying structure. Contraction of the elongated body can cause the first modifying structure and the second modifying structure to move towards each other; where movement of at least one of the first modifying structure or the second modifying structures can be configured to modify the conduit line. The conduit line may comprise mechanical cables, electrical conductors, optical fibers, or brittle portions that readily shatter.

Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: An appliance, system, and method for operating laundry appliances are provided. The method includes generating a plurality of utilization signals including a utilization rate corresponding to a first plurality of appliances at a first location; determining an activity status based on the plurality of utilization signals of the first plurality of appliances at the first location; determining a demand status based on comparing the activity status to a quantity of user interface devices within range of a network; and generating a user control signal based on the demand status.

Abstract: An appliance, system, and method for operating a laundry appliance are provided. The laundry appliance includes a controller configured to execute instructions that cause the appliance to perform operations. The operations include transmitting a utilization signal including a utilization rate of the appliance. The operations include obtaining a control signal based on an operation schedule. The operation schedule determines whether the appliance is under-utilized, over-utilized, or nominally utilized based on the utilization signal. The operations include adjusting operation of the appliance based on the control signal.

Abstract: A portable display unit 3000, 3500, 4000 for a breathing assistance apparatus, the portable display unit comprising: a display unit housing 3001, 3501, 4000; a screen 3051, 3551, 4051; and a tethering component for tethering the portable display unit 3000, 3500, 4000 with abase unit 50 of the breathing assistance apparatus.

Abstract: One aspect of the invention provides a three-dimensional scaffold including at least one layer of highly-aligned fibers. The at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers. Another aspect of the invention provides a method for fabricating a three-dimensional scaffold. The method includes: electro spinning a plurality of fibers to produce at least one layer of highly-aligned fibers and forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers. A further aspect of the invention provides methods for using a three-dimensional scaffold to treat nerve or spinal cord injury.

Abstract: Systems and methods are disclosed herein for adjusting flash intensity based on retinal pigmentation. In an embodiment, a processor determines a retinal pigmentation of a retina of an eye positioned at an imaging device. The processor commands the imaging device to adjust an intensity of a flash component from a first intensity to a second intensity based on the retinal pigmentation. The processor commands the imaging device to capture an image that is lit by the flash component at the second intensity, and receives the image from the imaging device.

Abstract: Techniques for anomaly detection are described. An exemplary method includes receiving one or more requests to train an anomaly detection machine learning model using feedback-based training, the request to indicate one or more of a type of analysis to perform, a model selection indication, and a configuration for a training dataset; training the anomaly detection machine learning model according to the one or more requests using the training data; performing feedback-based training on the trained anomaly detection machine learning model; and using the retrained anomaly detection machine learning model.

Abstract: An appliance includes an external communication port, such as an RJ45 port, and a wireless communication module in wireless communication with a remote server through an external network. In addition, a controller includes a boot loader segment and is configured to receive a request to access the boot loader segment of the controller, transmit a notification of the request to the remote server using the wireless communication module, receive an access determination from the remote server, e.g., such as an access authorization or denial from an owner, and regulate access to the boot loader segment based at least in part on the access determination.

Abstract: A container having a base and a lid is provided. The lid may be rotatable about a hinge from a closed configuration to an open configuration and may be secured, via one or more latching assemblies. The latching assembly may comprise a latch body, a locking member, a biasing member, and an activating member. Additional features of the container may include handles and strength increasing features. The base and lid may also feature attachment points for various accessories. A carry strap may attach to the base of the container to allow a user to lift and carry the container. The container may also have a wheels attached to the bottom portion and/or across the bottom portion to one side of the sidewall structure. In addition, in exemplary containers with wheels, a pull handle may be attached to a side opposite the wheels. The lid may include a lid support member that can act as a molle board to releasably secure items to the lid support member while also providing structural support to the lid.

Abstract: An interface system for connecting a vehicle and a transport climate control system (TCCS) is disclosed. The interface system includes a two-way communication interface that connects a vehicle electrical system (VES) controller and a TCCS controller. The interface system also includes a power interface that connects a vehicle energy source of the VES to the TCCS and a TCCS energy source of the TCCS to the VES. The two-way communication interface is configured to distribute a TCCS status from the TCCS controller to the VES controller, and is configured to distribute a VES status from the VES controller to the TCCS controller. The power interface is configured to distribute power from the vehicle energy source to the TCCS when a VES instruction is received, and distribute power from the TCCS energy source to the VES when a TCCS instruction is received.

Abstract: Devices and methods for treatment of bodily lumens and sphincters are disclosed. Some embodiments include methods and devices for inducing an inflammatory response and development of fibrosis, collagen, and/or scar tissue. In some embodiments, scaffolds may be composed of a matrix of filaments. Application of the methods and devices disclosed herein to treat Gastroesophageal Reflux Disease (GERD) and other sphincter disorders are discussed. Biodegradable scaffolds configured to induce an inflammatory response are also disclosed.

Abstract: The present disclosure is directed to embodiments of a tower structure with at least partially additively manufactured, stacked tower sections. Embodiments of the tower structure have a plurality of stacked tower sections, wherein at least one tower section of the plurality of stacked tower sections includes a wall element having one or more printed layers, and a base holding thereon the one or more printed layers. The present disclosure also is directed to a method of manufacturing a tower structure using a stacked tower sections and additive manufacturing. Embodiments of the method include forming a base of poured concrete or cast material, printing and depositing one or more printed layers to form a wall element, and stacking the plurality of tower sections to form the tower structure.

Abstract: Devices and methods for treatment of bodily lumens and sphincters are disclosed. Some embodiments include methods and devices for inducing an inflammatory response and development of fibrosis, collagen, and/or scar tissue. In some embodiments, scaffolds may be composed of a matrix of filaments. Application of the methods and devices disclosed herein to treat Gastroesophageal Reflux Disease (GERD) and other sphincter disorders are discussed. Biodegradable scaffolds configured to induce an inflammatory response are also disclosed.

Abstract: One aspect can provide a direct current (DC) feedback circuit. The DC feedback circuit can include a gain path, a first feedback capacitor coupled, in parallel, to the gain path, and an input resistor coupled to an input of the gain path and the first feedback capacitor. The gain path can include an input stage with a pair of transconductance amplifiers, a gain stage with one or more amplifiers, and an output stage with at least one negative feedback amplifier.

Abstract: Levers with fulcrums and other linkages can be structured to provide motion in many different structural formations by making adjustments to the parameters of a mechanism such as this invention. Mechanisms with multiple levers working together in coordination and moving a fraction of the full actuation allows machines to be built more efficiently. The levers can be connected to each other in multiple configurations which allow for these machines to be built and programmed from how the levers are connected to each other. This invention is modular so building complex actuators is a simple procedure. The machine can be used as a mechanical actuator or a projectile launcher or a programmable moving mechanism where the programming is built in the structure. By using levers, and simple energy mechanisms to power this invention, the overall efficiency of some processes can be increased.