Patents by Inventor Ryan K. Henning

Ryan K. Henning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOSPHORYLATED AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
    Publication number: 20230019342
    Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
    Type: Application
    Filed: June 27, 2022
    Publication date: January 19, 2023
    Inventors: James R. Heath, Arundhati Nag, Samir Das, Joseph O. Varghese, Ryan K. Henning
  • Phosphorylated Akt-specific capture agents, compositions, and methods of using and making
    Patent number: 11371994
    Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 28, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: James R. Heath, Arundhati Nag, Samir Das, Joseph O. Varghese, Ryan K. Henning
  • Cyclic peptide binder against oncogenic K-Ras
    Patent number: 10913774
    Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: February 9, 2021
    Assignee: California Institute of Technology
    Inventors: Ryan K. Henning, Ashwin N. Ram, Samir Das, Arundhati Nag, James R. Heath
  • CYCLIC PEPTIDE BINDER AGAINST ONCOGENIC K-RAS
    Publication number: 20180319844
    Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 8, 2018
    Inventors: Ryan K. Henning, Ashwin N. Ram, Samir Das, Arundhati Nag, James R. Heath
  • Cyclic peptide binder against oncogenic K-Ras
    Patent number: 10017540
    Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: July 10, 2018
    Assignee: California Institute of Technology
    Inventors: Ryan K. Henning, Ashwin N. Ram, Samir Das, Arundhati Nag, James R. Heath
  • CYCLIC PEPTIDE BINDER AGAINST ONCOGENIC K-RAS
    Publication number: 20160264627
    Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Inventors: Ryan K. Henning, Ashwin N. Ram, Samir Das, Arundhati Nag, James R. Heath
  • PHOSPHORYLATED AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
    Publication number: 20150219657
    Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 6, 2015
    Inventors: James R. Heath, Arundhati Nag, Samir Das, Joseph O. Varghese, Ryan K. Henning