Abstract: Described herein are passive nasal respiratory devices, in particular, passive nasal respiratory devices configured to achieve positive end-expiratory pressure (PEEP) in a subject wearing the device. PEEP devices may have a threshold pressure for opening during expiration. These devices may include a flap valve that opens on inhalation nested with a spring valve that opens when exhalation pressure exceeds a predetermined threshold. The device may be configured to be comfortably worn by a sleeping subject.

Abstract: Described herein are passive nasal respiratory devices, in particular, passive nasal respiratory devices configured to achieve positive end-expiratory pressure (PEEP) in a subject wearing the device. PEEP devices may have a threshold pressure for opening during expiration. These devices may include a flap valve that opens on inhalation nested with a spring valve that opens when exhalation pressure exceeds a predetermined threshold. The device may be configured to be comfortably worn by a sleeping subject.

Abstract: Described herein are passive nasal respiratory devices, in particular, passive nasal respiratory devices configured to achieve positive end-expiratory pressure (PEEP) in a subject wearing the device. PEEP devices may have a threshold pressure for opening during expiration. These devices may include a flap valve that opens on inhalation nested with a spring valve that opens when exhalation pressure exceeds a predetermined threshold. The device may be configured to be comfortably worn by a sleeping subject.

Abstract: Improved passive resistance nasal devices for treating a patient (and particularly, but not exclusively, a sleeping patient) that inhibit exhalation more than inhalation. For example, described herein are passive-resistance nasal devices having a variable sized opening leak path that change the size of the leak path opening depending on the pressure extended across the nasal device. Also described herein are passive nasal devices including a deployable insertion guide member. Also described herein are passive nasal devices including an extension member to hold the airflow resistor portion of the nasal device slightly apart from the subject's nose, even as the nasal device itself may be secured against the nose or nostril openings. Methods of operating these nasal devices and methods of treating patients using these devices are also described.

Abstract: Described herein are passive nasal respiratory devices, in particular, passive nasal respiratory devices configured to achieve positive end-expiratory pressure (PEEP) in a subject wearing the device. PEEP devices may have a threshold pressure for opening during expiration. These devices may include a flap valve that opens on inhalation nested with a spring valve that opens when exhalation pressure exceeds a predetermined threshold. The device may be configured to be comfortably worn by a sleeping subject.

Abstract: This is a balloon catheter having at least two lumens. One of the lumens is a large working lumen. The balloon catheter is especially useful as a guide catheter or micro catheter and may be used in a variety of therapeutic and diagnostic procedures. In particular, it has value in treating neurovascular embolic strokes in combination with other devices which are delivered to the stroke site through that working lumen. The remainder of the lumens typically are used to inflate and to deflate the balloon.

Abstract: Described herein are passive nasal device having a resistance to exhalation that is greater than the resistance to inhalation. Also described are devices, methods and systems for sensing and measuring intranasal pressure when a subject is wearing a passive nasal respiratory device that is configured to inhibit exhalation more than inhalation. Also described are adapters for nasal devices and methods of using a nasal device adapter. Adapters may be used so that a passive nasal device may be applied indirectly in communication with a subject's nose; in some variations this may allow the passive nasal device to be re-used. Also described herein are nasal devices having a billowing airflow resistor that is configured to have a greater resistance to exhalation than to inhalation.

Abstract: This is a balloon catheter having at least two lumens. One of the lumens is a large working lumen. The balloon catheter is especially useful as a guide catheter or micro catheter and may be used in a variety of therapeutic and diagnostic procedures. In particular, it has value in treating neurovascular embolic strokes in combination with other devices which are delivered to the stroke site through that working lumen. The remainder of the lumens typically are used to inflate and to deflate the balloon.

Abstract: This is directed to containers and methods for holding and delivering vaso-occluding materials such as hydrogel particles and filaments. The vaso-occlusive materials may be held in the container in a hydrated or unhydrated state. The container includes a fluid ingress port and a fluid egress port that are respectively fluidly connectable with a fluid source and a delivery catheter. The container further includes at least one chamber or passageway extending therebetween. The passageway may be straight, curved, spiral, helical, narrow or otherwise shaped. The chamber may also have sections of varying cross section such as a ramped section. The shapes of the passageways of the container help organize ejection of the vaso-occluding materials minimizing contamination and clumping. Methods for holding and introducing the materials are also provided.

Abstract: A delivery system for placement of implantable occlusive devices allows placement of the devices place at selected treatment sites in the vascular system. Occlusive filaments produced from gel polymers are delivered by apparatus comprising various grippers, engagers, and couplers that are capable of holding onto the often slippery occlusive devices and of releasing and selectively severing them at desired treatment sites within the human body.

Abstract: This is a surgical device. Specifically disclosed is a delivery system for placement of implantable occlusive devices. In particular, the occlusive devices may be placed at selected treatment sites in the vascular system. The major variation described here is a combination of occlusive filaments produced from gel polymers and various grippers, engagers, and couplers that are capable of holding onto the often slippery occlusive devices and of releasing them at desired treatment sites within the human body. Processes for use of such devices are also included.

Abstract: Containers for holding and delivering vaso-occluding materials, such as hydrogel particles and filaments include a fluid inlet port and a fluid outlet port that are respectively fluidly connectable with a fluid source and a delivery catheter. The vaso-occlusive materials may be held in the container in a hydrated or unhydrated state. The container further includes at least one chamber or passageway extending therebetween. The passageway may be straight, curved, spiral, helical, narrow or otherwise shaped. The chamber may also have sections of varying cross section such as a ramped section. The shapes of the passageways of the container help organize ejection of the vaso-occluding materials minimizing contamination and clumping.

Abstract: This is a balloon catheter having at least two lumens. One of the lumens is a large working lumen. The balloon catheter is especially useful as a guide catheter or micro catheter and may be used in a variety of therapeutic and diagnostic procedures. In particular, it has value in treating neurovascular embolic strokes in combination with other devices which are delivered to the stroke site through that working lumen. The remainder of the lumens typically are used to inflate and to deflate the balloon.

Abstract: This is directed to containers and methods for holding and delivering vaso-occluding materials such as hydrogel particles and filaments. The vaso-occlusive materials may be held in the container in a hydrated or unhydrated state. The container includes a fluid ingress port and a fluid egress port that are respectively fluidly connectable with a fluid source and a delivery catheter. The container further includes at least one chamber or passageway extending therebetween. The passageway may be straight, curved, spiral, helical, narrow or otherwise shaped. The chamber may also have sections of varying cross section such as a ramped section. The shapes of the passageways of the container help organize ejection of the vaso-occluding materials minimizing contamination and clumping. Methods for holding and introducing the materials are also provided.