Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a prosthetic valve. The prosthetic valve may include a jacket configured to cover at least one of gaps, spaces, or interfaces in a frame or between one or more leaflets attached to the frame.

Abstract: In general, the systems and methods described in this application relate to laser-induced nucleation in continuous flow. A method of laser-induced nucleation in continuous flow includes injecting a saturated solution, undersaturated solution, or supersaturated solution through an inlet of a device. The method can include converting the saturated solution or undersaturated solution into supersaturated solution by changing a temperature of the saturated solution or undersaturated solution. The method can include passing one or more laser pulses through the supersaturated solution within the device. The method can include flowing the saturated solution, undersaturated solution, or the supersaturated solution through an outlet of the device.

Abstract: In general, the systems and methods described in this application relate to laser-induced nucleation in continuous flow. A method of laser-induced nucleation in continuous flow includes injecting a saturated solution, undersaturated solution, or supersaturated solution through an inlet of a device. The method can include converting the saturated solution or undersaturated solution into supersaturated solution by changing a temperature of the saturated solution or undersaturated solution. The method can include passing one or more laser pulses through the supersaturated solution within the device. The method can include flowing the saturated solution, undersaturated solution, or the supersaturated solution through an outlet of the device.

Abstract: Systems and methods related to handling solids in microfluidic systems are generally described. Many of the systems and methods described herein address the need to inhibit the formation of blockages in microfluidic channels.

Abstract: The present invention generally relates to the small-scale separation of a mixture of two or more components with different boiling points into enriched fractions. In some embodiments, a first and second fluid (e.g., a liquid and a gas, a liquid and a liquid, etc.) are passed through a channel. The first fluid may include at least two components, each with a unique boiling point. Upon contacting the first and second fluids within the channel, at least a portion of the most volatile of the components in the first fluid (i.e., the component with the lowest boiling point) may be transferred from the first fluid to the second fluid. In some instances, the transfer of the volatile component(s) from the first fluid to the second fluid may be expedited by heating, in some cases above the boiling point(s) of the component(s) to be transferred from the first fluid to the second fluid. Contact between the first and second fluids may be maintained, for example, via segmented flow, bubbling flow, etc.

Abstract: Systems and methods related to handling solids in microfluidic systems are generally described. Many of the systems and methods described herein address the need to inhibit the formation of blockages in microfluidic channels.

Abstract: The present invention generally relates to the small-scale separation of a mixture of two or more components with different boiling points into enriched fractions. In some embodiments, a first and second fluid (e.g., a liquid and a gas, a liquid and a liquid, etc.) are passed through a channel. The first fluid may comprise at least two components, each with a unique boiling point. Upon contacting the first and second fluids within the channel, at least a portion of the most volatile of the components in the first fluid (i.e., the component with the lowest boiling point) may be transferred from the first fluid to the second fluid. In some instances, the transfer of the volatile component(s) from the first fluid to the second fluid may be expedited by heating, in some cases above the boiling point(s) of the component(s) to be transferred from the first fluid to the second fluid. Contact between the first and second fluids may be maintained, for example, via segmented flow, bubbling flow, etc.