Patents by Inventor Ryan L. Wong

Ryan L. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF DESIGNING HIGHLY REGULATED LENTIVIRAL VECTORS POSSESING STRICT ENDOGENOUS REGULATION
    Publication number: 20240082427
    Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).
    Type: Application
    Filed: January 28, 2022
    Publication date: March 14, 2024
    Applicant: The Regents of the University of California
    Inventors: Donald B. Kohn, Ryan L. Wong, Roger Paul Hollis, Richard A. Morgan, Aaron Ross Cooper
  • LENTIVIRAL VECTORS IN HEMATOPOIETIC STEM CELLS TO TREAT WISKOTT-ALDRICH SYNDROME (WAS)
    Publication number: 20220387528
    Abstract: In certain embodiments a lentiviral vector for the treatment of Wiskott-Aldrich Syndrome (WAS) is provided. In certain embodiments the vector comprises an expression cassette comprising a nucleic acid construct comprising an effective fragment of the endogenous promoter of the WAS gene where said promoter has maximum length of 600 bp and contains the sequence of HS1pro, and a nucleic acid that encodes the Wiskott-Aldrich Syndrome protein (WASp) operably linked to the effective fragment of the endogenous promoter of the WAS gene.
    Type: Application
    Filed: November 10, 2020
    Publication date: December 8, 2022
    Applicant: The Regents of the University of California
    Inventors: Donald B. Kohn, Ryan L. Wong, Roger Paul Hollis
  • LENTIVIRAL VECTORS IN HEMATOPOIETIC STEM CELLS TO TREAT RECOMBINATION-ACTIVATING GENE 1 (RAG1) SEVERE COMBINED IMMUNODEFICIENCY (SCID)
    Publication number: 20220389454
    Abstract: In certain embodiments a lentiviral vector for the treatment of Recombination-Activating Gene 1 Severe Combined Immunodeficiency (RAG1 SCID) is provided. In certain embodiments the vector comprises an expression cassette comprising a nucleic acid construct comprising an effective fragment of the endogenous promoter of the RAG1 gene and a nucleic acid that encodes the RAG1 protein operably linked to the effective fragment of the endogenous promoter of the RAG1 gene.
    Type: Application
    Filed: November 12, 2020
    Publication date: December 8, 2022
    Applicant: The Regents of the University of California
    Inventors: Donald B. Kohn, Ryan L. Wong, Roger Paul Hollis, Richard A. Morgan
  • LENTIVIRAL VECTORS IN HEMATOPOIETIC STEM CELLS TO TREAT X-LINKED CHRONIC GRANULOMATOUS DISEASE
    Publication number: 20220378937
    Abstract: In certain embodiments a lentiviral vector for the treatment of X-linked chronic granulomatous disease (X-CGD) is provided. In certain embodiments the vector comprises an expression cassette comprising a nucleic acid construct comprising a CYBB promoter or effective fragment thereof; and a nucleic acid that encodes gp91phox operably linked to the CYBB promoter or promoter fragment.
    Type: Application
    Filed: November 12, 2020
    Publication date: December 1, 2022
    Applicant: The Regents of the University of California
    Inventors: Donald B. Kohn, Ryan L. Wong, Roger Paul Hollis