Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties.

Abstract: An article of furniture includes a seat assembly that includes a rectangular seat support frame and a rest mount arranged on each of at least two adjacent sides of the seat support frame. A rest assembly includes a rectangular rest support frame and a seat mount arranged on at least one side of the rest support frame. The article of furniture includes at least one elongate connector, the, or each, elongate connector having a first portion that is engageable, in a detachable manner, with either of the rest mounts, and a second portion that is engageable, in a detachable manner, with the seat mount.

Abstract: The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties.

Abstract: A rest component (14), (16) for an article of furniture (10) includes a body member (32) defining a plurality of surfaces (34). A cover member (36) is carried by at least one surface (34) of the body member (32) to define a pocket (38) associated with the at least one surface (34), the pocket (38) defining a mouth to enable a user to gain access to an interior of the pocket (38). At least one passage (24) is defined by at least one of the body member (32) and the cover member (36) and opening out into the pocket (38). The passage (24) is configured to accommodate an elongate element which extends through the passage to exit from an operatively bottom region of the body member.

Abstract: An operating system (10) for operating an article of furniture (12), the article of furniture (12) comprising a support structure, at least one component displaceably arranged relative to the support structure and a receiver. The operating system (10) includes a (controller 34) which communicates wirelessly with the article of furniture (12), the controller (34) outputting operating signals (46) containing operating instructions. A signal processing module communicates with the wireless controller (34) via a routing arrangement (48), the signal processing module receiving the operating signals (46) and converting the operating signals into control signals to be provided to the receiver to effect displacement of the at least one component of the article of furniture (12) relative to the support structure under the control of a user.

Abstract: A rest component (12, 14) for an article of furniture (10) includes a body member (16) mountable to a platform (18) of the article of furniture (10), the body member (16) defining a plurality of surfaces (20). A cover member (26) is carried by the body member (16) to define a pocket (32) associated with at least one surface (20) of the body member (16), the pocket (32) defining a mouth (34) to enable a user to gain access to an interior of the pocket (32). At least one receiving formation (36) is carried by the body member (16) within the pocket (32), the cover member (26) concealing the at least one receiving formation (36).