Patents by Inventor Ryan Lee Coe

Ryan Lee Coe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optical projection tomography microscopy (OPTM) for large specimen sizes
    Patent number: 10557778
    Abstract: An imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images is disclosed. One embodiment includes a light source and an imaging system having an adjustable focal position, which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also disclosed is a system and method for preparing a specimen for optical microscopy. One embodiment includes fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: February 11, 2020
    Inventors: Eric J. Seibel, Qin Miao, Ryan Lee Coe, Per G. Reinhall
  • OPTICAL PROJECTION TOMOGRAPHY MICROSCOPY (OPTM) FOR LARGE SPECIMEN SIZES
    Publication number: 20140342395
    Abstract: Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 20, 2014
    Inventors: Eric J. Seibel, Qin Miao, Ryan Lee Coe, Per G. Reinhall
  • Optical projection tomography microscopy (OPTM) for large specimen sizes
    Patent number: 8867803
    Abstract: Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 21, 2014
    Inventors: Eric J. Seibel, Qin Miao, Ryan Lee Coe, Per G. Reinhall
  • Optical Projection Tomography Microscopy (OPTM) for Large Specimen Sizes
    Publication number: 20120196320
    Abstract: Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
    Type: Application
    Filed: April 20, 2011
    Publication date: August 2, 2012
    Inventors: Eric J. Seibel, Qin Miao, Ryan Lee Coe, Per G. Reinhall, Duane W. Storti