Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A method of generating thickened collagen bundles or clusters, comprising the steps of: preparing a neutralized collagen gel sample; warming the neutralized collagen gel sample to provide a warmed neutralized collagen gel sample; and agitating the warmed neutralized collagen gel sample to provide an agitated collagen gel sample.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to detecting inbound and outbound traffic. In some embodiments, there is provided a system for detecting inbound and outbound traffic at a facility including a video camera and a control circuit configured to detect a human and estimate a location of the human; determine whether the detected human is inbound or outbound the facility based on a relative movement of the detected human within a first region, a second region, and a third region; and transmit data based on the determination.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to automatically annotating images. In some embodiments, a system for automatically annotating images comprises a database, wherein the database is configured to store images and annotations for the images and a control circuit, wherein the control circuit is communicatively coupled to the database, and wherein the control circuit is configured to retrieve, from the database, an image, generate, based on the image, a collection of augmented images, generate segmentation maps for each image in the collection of augmented images, wherein each of the segmentation maps include segments, select, based on a threshold, ones of the segments above a threshold, merge the ones of the segments above the threshold to create a segmented image, and generate, for each segment of the segmented image, classifications, wherein an annotation for the image includes the segmented images and the classifications.

Abstract: Techniques are described herein that are capable of automatic mapping of a question or compliance controls associated with a compliance standard to compliance controls associated with another compliance standard. Reference controls having respective first subsets of text-based features are identified. A question having a second subset of the text-based features or custom controls having respective second subsets of the text-based features are identified. Scores for the respective reference controls are determined for the question or each custom control using a supervised natural language processing machine learning model based at least on the first subsets of the text-based features and the second subset(s) of the text-based features. A compliance map is generated by automatically mapping the question or each custom control to a respective subset of the reference controls using the supervised natural language processing machine learning model based at least on the scores.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: Embodiments of the disclosed technologies receive first event data associated with a first party application, receive second event data representing a click, in the first party application, on a link to a third party application, receive third event data from the third party application, convert the third event data to a label, map a compressed format of the labeled third event data to the first event data and the second event data to create multi-party attribution data, group multiple instances of the multi-party attribution data into a batch, add noise to the compressed format of the labeled third event data in the batch, and send the noisy batch to a second computing device. A debiasing algorithm can be applied to the noisy batch. The debiased noisy batch can be used to train at least one machine learning model.

Abstract: Embodiments of the present disclosure relate to a method, device, apparatus and computer readable medium for sidelink positioning. According to embodiments of the present disclosure, a second device transmits information related to sidelink positioning to a first device. The information indicates that the second device is able to assist with the sidelink positioning and comprises assistance information for the sidelink positioning. The first device selects at least one proper device for the sidelink positioning based on the assistance information. In this way, it improves accuracy of the sidelink positioning.

Abstract: Embodiments of the present disclosure relate to a method, apparatus and computer readable storage medium for positioning beam management. According to embodiments of the present disclosure, a terminal device determines signal quality and a time of arrival of a positioning reference signal received from a network device and identifies a positioning beam failure based at least in part on the determined signal quality and the time of arrival of the positioning reference signal.

Abstract: A functionalized macromolecule includes a hydrogenated interpolymer portion, a non-hydrogenated polymer portion, and the radical of a functional coupling agent covalently bonded to and linking those portions. The functional group of the coupling agent exhibits interactivity with silica. The interpolymer can include vinyl aromatic mer and conjugated diene mer, with at least some of the latter, typically at least 50 mole percent, having been hydrogenated.

Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Abstract: A method for a base station includes sending a request for a report on beamforming capability to a target user equipment; receiving the report on the beamforming capability from the target user equipment; allocating at least one positioning reference signal resource for use by the target user equipment based on at least the capability information included in the report; determining a beam sweeping mle based on the at least one positioning reference signal resource allocated for the target user equipment; and sending the positioning reference signal resource allocation and the beam sweeping mle to the target user equipment.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to detecting text in images. In some embodiments, a system for detecting text in images comprises a database configured to store images and a control circuit configured to retrieve an image, generate, based on the image, a collection of augmented images, detect characters in each of the augmented images, generate bounding boxes for the characters in each of augmented images, recognize the characters in each of the augmented images, select, based on the recognition of the characters in each of the augmented images, candidate characters, wherein the candidate characters are selected based on consistency of the recognition of the characters in each of the augmented images, detect, for the image, a color associated with the characters, and store, in the database, the image, the candidate characters, and the color associated with the characters.

Abstract: A mobile software application implementing “live events,” via which a host of the event may sequentially offer one, two, three, four or more items to a plurality of guests in the event (e.g., via auction, via direct purchase, or via a giveaway). The host's device may obtain and transmit a real-time video stream, which is in turn provided to each guest's device in conjunction with real-time information about the item(s) being offered. Particular techniques further assist the host in sequencing two or more items to be offered in the same live event, thereby avoiding delays and cumbersome user interface interactions that might otherwise be involved in initiating the offering of a next item upon concluding an offering of a previous item.

Abstract: Dental appliances and methods for expanding the lower dental arch. The appliances may be removable mandibular expander devices for efficient arch expansion while being comfortable to wear and easy to use. The appliances may include a lingual portion that is shaped and sized to apply an expansion force to lingual surfaces of one or more teeth. The shape and size of the lingual portion may be configured to distribute the forces among posterior and/or anterior teeth.

Abstract: In certain embodiments, the use of re-usable cold storage keys to sign messages may be facilitated. In some embodiments, an offline computer system (operating within an offline computing environment) may obtain, from a removable computer-readable storage medium, signing key shards corresponding to a signing private key and a blockchain transaction to be signed, where the signing key shards satisfy a key shard threshold that is (i) a number of key shards required for reconstructing the signing private key and (ii) less than a number of key shards derived from the signing private key using a ceremony key. The offline computer system may form a ciphertext of the signing private key using the signing key shards and reconstruct the signing private key by decrypting the ciphertext using the ceremony key. The offline computer system may sign the blockchain transaction using the signing private key.

Abstract: A surface cleaning device includes a nozzle and an odor dial assembly. The nozzle includes a nozzle housing and a dirty air passageway. The odor dial assembly include a fragrance member and a dial body configured to be removably coupled to the nozzle housing. The dial body at least partially defines a fragrance cavity configured to at least partially receive the fragrance member and a fragrance passageway extending therethrough. The odor dial assembly is configured to transition between a plurality of user-selectable positions to adjust an amount of fragrance particles released by the fragrance member into the dirty air passageway.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: Method and system for processing a point cloud frame representing a real-world scene that includes one or more objects, including assigning data-element-level classification labels to data elements that each respectively represent one or more points included in the point cloud frame, estimating an approximate position of a first object instance represented in the point cloud frame, assigning an object-instance-level classification label to the first object instance, selecting, for the first object instance, a subgroup of the data elements based on the approximate position, selecting from the subgroup a first cluster of data elements that have assigned data-element-level classification labels that match the object-instance-level classification label assigned to the first object instance, and outputting an object instance list that indicates, for the first object instance, the first cluster of data elements, and the object-instance-level classification label assigned to the first object instance.

Abstract: An online system accesses a machine learning model trained to predict behaviors of users of the online system, in which the model is trained based on historical data received by the online system that is associated with the users and demand and supply sides associated with the online system. The online system identifies a treatment for achieving a goal of the online system and simulates application of the treatment on the demand and supply sides based on the historical data and a set of behaviors predicted for the users. Application of the treatment is simulated by replaying the historical data in association with application of the treatment and applying the model to predict the set of behaviors while replaying the data. The online system measures an effect of application of the treatment on the demand and supply sides based on the simulation, in which the effect is associated with the goal.