Patents by Inventor Ryan Lyski

Ryan Lyski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CAMPTOTHECIN CONJUGATES
    Publication number: 20230381321
    Abstract: Antibody conjugates with camptothecin compounds are described, with methods of use and preparations.
    Type: Application
    Filed: March 16, 2023
    Publication date: November 30, 2023
    Inventors: Ryan LYSKI, Philip MOQUIST, Nicole DUNCAN, Scott JEFFREY
  • SELECTIVE DRUG RELEASE FROM INTERNALIZED CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS
    Publication number: 20230091653
    Abstract: The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or improves biodistribution into the tumor tissue in comparison to normal tissue homogenate from the same species, wherein the normal tissue is the site of an adverse event associated with administration to a human subject in need thereof of a therapeutically effective amount of a comparator conjugate whose amino acid sequence is a dipeptide known to be selectively cleavable by Cathepsin B.
    Type: Application
    Filed: March 17, 2022
    Publication date: March 23, 2023
    Inventors: Noah BINDMAN, Nicole OKELEY, Peter SENTER, Divya AWASTHI, Vivian TRANG, Ryan LYSKI, Scott JEFFREY, Roozbeh YOUSEFI, Bradley GORSLINE
  • CAMPTOTHECIN CONJUGATES
    Publication number: 20230036256
    Abstract: Antibody conjugates with camptothecin compounds are described, with methods of use and preparations.
    Type: Application
    Filed: June 7, 2019
    Publication date: February 2, 2023
    Inventors: Scott JEFFREY, Ryan LYSKI, Uland LAU
  • CAMPTOTHECIN PEPTIDE CONJUGATES
    Publication number: 20220193069
    Abstract: Provided herein are Camptothecin Conjugates, Camptothecin-Linker Compounds, Camptothecin Compounds, intermediates thereof, and method of preparing the same. Also provided herein are methods of treating cancer and autoimmune diseases with the Conjugates described herein.
    Type: Application
    Filed: October 27, 2021
    Publication date: June 23, 2022
    Inventors: Scott JEFFREY, Ryan Lyski, Maureen Ryan, Julia Cochran
  • CAMPTOTHECIN PEPTIDE CONJUGATES
    Publication number: 20190343828
    Abstract: Provided herein are Camptothecin Conjugates, Camptothecin-Linker Compounds, Camptothecin Compounds, intermediates thereof, and method of preparing the same. Also provided herein are methods of treating cancer and autoimmune diseases with the Conjugates described herein.
    Type: Application
    Filed: April 5, 2019
    Publication date: November 14, 2019
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Scott Jeffrey, Ryan Lyski, Maureen Ryan, Julia Cochran