Patents by Inventor Ryan M. Fox

Ryan M. Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRPV4 antagonists
    Patent number: 8658636
    Abstract: The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: February 25, 2014
    Assignee: GlaxoSmithKline, LLC
    Inventors: Carl A. Brooks, Mui Cheung, Hilary S. Eidam, Ryan M. Fox, Mark A. Hilfiker, Eric S. Manas, Guosen Ye
  • TRPV4 ANTAGONISTS
    Publication number: 20130012499
    Abstract: The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
    Type: Application
    Filed: March 23, 2011
    Publication date: January 10, 2013
    Applicant: GlaxoSmithKline LLC
    Inventors: Carl A. Brooks, Mui Cheung, S. Eidam Hilary, Ryan M. Fox, Mark A. Hilfiker, Eric S. Manas
  • Amide forming chemical ligation
    Patent number: 7737293
    Abstract: An amide is formed by reacting an ?-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the ?-carbon of the ketoacid and the nitrogen of the amine. The ?-ketoacid can be formed using a novel sulfur reagent.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: June 15, 2010
    Assignee: Regents of the University of California
    Inventors: Jeffrey W. Bode, Ryan M. Fox
  • Amide forming chemical ligation
    Patent number: 7667076
    Abstract: An amide is formed by reacting an ?-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the ?-carbon of the ketoacid and the nitrogen of the amine. The ?-ketoacid can be formed using a novel sulfur reagent.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: February 23, 2010
    Assignee: Regents of the University of California
    Inventors: Jeffrey W. Bode, Ryan M. Fox
  • Amide Forming Chemical Ligation
    Publication number: 20090069536
    Abstract: An amide is formed by reacting an ?-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the ?-carbon of the ketoacid and the nitrogen of the amine. The ?-ketoacid can be formed using a novel sulfur reagent.
    Type: Application
    Filed: November 10, 2008
    Publication date: March 12, 2009
    Inventors: Jeffrey W. Bode, Ryan M. Fox