Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A system is provided wherein a devolatilizing reactor is used to make combinatorial libraries of materials. Examples of suitable reactors include continuous high viscosity devolatilizers and continuous devolatilizing kneaders.

Abstract: Disclosed are block copolymers and end-functionalized polymers containing in their backbones at least one fluoro alkyl (meth)acrylate mer unit comprising —C6F13, —C4F9, or —C3F7.

Abstract: Certain block copolymers may be suitable as compatibilizers in multiple component polymeric blends and composites. The utilization of at least one block copolymer in polymeric blends augments physical properties in the polymeric blend composite. The addition of block copolymers to polymeric blends may enhance certain mechanical properties of the composite, such as tensile strength, impact resistance, modulus, and heat stability, over the initial levels achieved by polymeric blends without incorporating block copolymers.

Abstract: Provided are compositions comprising a polymeric matrix; a plurality of fillers; and a block copolymer wherein at least one segment of the block copolymer interacts with the fillers. Also provided are composition comprising a plurality of fillers having surfaces and a block copolymer wherein at least one segment of the block copolymer is capable of interacting with the fillers upon application in a polymeric matrix. Compositions comprising a flame retardant compound and a block copolymer wherein at least one segment of the block copolymer is capable of interacting with the flame retardant compound upon application in a polymeric matrix are also provided.

Abstract: A deprotectable polymer, activating agent, and layered silicate are combined and the deprotectable polymer is at least partially deprotected to form a composite. The composite may be combined with a polymeric resin to form a nanocomposite.

Abstract: Block copolymers are suitable additives for polymeric composites containing microspheres. The block copolymers have at least one segment that is capable of interacting with the microspheres thereby enhancing the physical characteristics of the composition.

Abstract: A composition comprising exfoliated silicate platelets; a thermoplastic polymer; and a block copolymer and method of making the same.

Abstract: A mixture of layered silicate, block copolymer having at least one block that is compatible with the first layered silicate, and a solvent is sheared while the solvent is removed.

Abstract: A composition comprising a fluorinated block copolymer and at least one of an intercalated layered silicate or exfoliated silicate platelets, and methods of making the same.

Abstract: A method of continuous polymerization using differential radial stirring is provided. Particularly suited for this method is a stirred tube reactor with a plurality of collinear stirring shafts that may rotate independently.

Abstract: Disclosed are block copolymers and end-functionalized polymers containing in their backbones at least one fluoro alkyl (meth)acrylate mer unit comprising —C6F13, —C4F9, or —C3F7.

Abstract: Disclosed are block copolymers and end-functionalized polymers containing in their backbones at least one fluoro alkyl (meth)acrylate mer unit comprising —C6F13, —C4F9, or —C3F7.

Abstract: The device of the present invention delivers reactants to a reaction zone in a plug flow reactor. The feedblock encircles the reaction zone. Reactants enter the feedblock through an inlet port leading to a manifold for the delivery of reactants into a plurality of feed ports that are in connection with the reaction zone of a plug flow reactor. The invention additionally encompasses plug flow reactors including one or more feedblocks and the method of utilizing the feedblock for the reduction of radial variation in concentration upon entry of a reactant into the reaction zone.