Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: The presently disclosure relates to a system and method for bioelectronic communications. In certain embodiments the system comprises a bacterial cell or cells that comprise a genetic system for high-efficiency over-expression and secretion of recombinant proteins in bacteria. In certain embodiments, the system and method operate in a “pump-then-burst release” fashion to rapidly achieve high yields extracellularly. In certain embodiments, the system and method include quorum sensing-derived regulation, which may enable auto-induction of a protein's expression and secretion.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: According to an example embodiment there is provided an unmanned aerial vehicle (UAV), the UAV including: a first rotor, the first rotor having a diameter and a first number of blades; and a second rotor, the second rotor having a diameter and a second number of blades; wherein the first and second rotor are substantially coaxial; and wherein the first number and the second number are not the same number and are both more than one.

Abstract: Traffic signal control systems and methods in accordance with various embodiments of the invention are disclosed. One embodiment includes: at least one image sensor mounted with a bird's eye view of an intersection; memory containing a traffic optimization application and classifier parameters for a plurality of classifiers, where each classifier is configured to detect a different class of object; a processing system. In addition, the traffic optimization application directs the processing system to: capture image data using the at least one image sensor; search for pedestrians and vehicles visible within the captured image data by performing a plurality of classification processes based upon the classifier parameters for each of the plurality of classifiers; determine modifications to the traffic signal phasing based upon detection of at least one of a pedestrian or a vehicle; and send traffic signal phasing instructions to a traffic controller directing modification to the traffic signal phasing.

Abstract: There is provided a system and apparatus comprising a fastener component of novel geometry. There is further provided systems and apparatuses comprising a fastener component that communicates information in additional to providing mechanical attachment. There is still further provided novel substrates for fastener systems and assemblies.