Abstract: Systems and methods for imaging a target feature of a subject based on the tracked positions of the subject and the target feature are disclosed. According to an aspect, a system includes a scanner configured to image a target feature of a subject. The system includes a mechanism configured to move the scanner. Further, the system includes a subject tracker configured to track positioning of the subject. The system includes a feature tracker configured to track positioning of the target feature. A controller is configured to control the mechanism to move the feature tracker to a position such that the feature tracker is operable to track a position of the target feature. The controller controls the mechanism to move the scanner to a position such that the scanner is operable to image the target feature based on the tracked position of the target feature by the feature tracker.

Abstract: A system includes a reflective mask positioned in a first plane, a digital micromirror device (DMD) that is positioned in a second plane to receive transmitted light from the reflective mask via a non-confocal channel. The DMD includes micromirrors that rotate between an ON state and an OFF state. The system further includes an ON image detector that captures ON image data of the transmitted light directed by the micromirrors in the ON state and an OFF image detector that captures OFF image data of the transmitted light directed by the micromirrors in the OFF state. A method of image reconstruction includes using the captured data to compare against artificial image data created by a machine learning model/reconstruction network and iteratively updating weights (e.g., of the machine learning model/reconstruction network) for generating an artificial image from the artificial image data until a minimum threshold is reached.

Abstract: A method of performing computational image contrast from multidimensional data includes receiving a plurality of images of an object, with each image of the plurality of images having more than three dimensions, performing multi-dimensional registration of the plurality of images to generate a multi-dimensional dataspace, reducing dimensionality of the multi-dimensional dataspace to create an enhanced resolution and contrast image of a 3D space of the object using the plurality of images as registered in the multi-dimensional dataspace, and displaying the enhanced resolution and contrast image. In some cases, reducing the dimensionality of the multi-dimensional dataspace to create the enhanced resolution and contrast image of the 3D space of the object comprises utilizing at least one of variance, high-order statistics, entropy, principal component analysis, t-distributed stochastic neighborhood embedding, and neural networks using the plurality of images as registered in the multi-dimensional dataspace.

Abstract: Peripheral retinal OCT can be used to generate peripheral retinal OCT images allowing for the peripheral retina to be viewed. A peripheral retinal vision system can determine that a set of fiducial markers is in a field-of-view of at least one camera and record positional data comprising a contact lens position and angle with respect to an OCT imaging system having OCT scanning mirrors in a first position. The system can determine whether a retinal layer is in an OCT scan captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position; and for an OCT scan having he retinal layer and being captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position, store that OCT scan.

Abstract: Systems and methods for imaging a target feature of a subject based on the tracked positions of the subject and the target feature are disclosed. According to an aspect, a system includes a scanner configured to image a target feature of a subject. The system includes a mechanism configured to move the scanner. Further, the system includes a subject tracker configured to track positioning of the subject. The system includes a feature tracker configured to track positioning of the target feature. A controller is configured to control the mechanism to move the feature tracker to a position such that the feature tracker is operable to track a position of the target feature. The controller controls the mechanism to move the scanner to a position such that the scanner is operable to image the target feature based on the tracked position of the target feature by the feature tracker.

Abstract: Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes a sample arm having an associated sample arm path and coupled to the source arm. The sample arm includes at least one optical component configured to simultaneously scan both an anterior and posterior portion of an eye of a subject.

Abstract: Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot at a pupil plane for image capture and during capture of the OCT images. The imaging system also includes a controller configured to control the scanner to relocate the OCT scan pivot at the pupil plane based on the determined movement of the eye.

Abstract: Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes a sample arm having an associated sample arm path and coupled to the source arm. The sample arm includes at least one optical component configured to simultaneously scan both an anterior and posterior portion of an eye of a subject.

Abstract: Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot at a pupil plane for image capture and during capture of the OCT images. The imaging system also includes a controller configured to control the scanner to relocate the OCT scan pivot at the pupil plane based on the determined movement of the eye.