Abstract: A Taylor cone emitter device automated handler is disclosed including an actuated Taylor cone emitter device manipulator, first, second, and third actuators configured to actuate the device manipulator horizontally, vertically, and between a vertical orientation and a horizontal orientation. The device manipulator includes a shaft, an emplacement configured to removably engage a receptacle mount of a Taylor cone emitter device, an ejector configured to dismount the receptacle mount, and a clocking feature interface configured to guide the Taylor cone emitter device into and fix it in a predetermined radial orientation. The Taylor cone emitter device automated handler is configured to mount the Taylor cone emitter device in the vertical orientation, rotate the Taylor cone emitter device to the horizontal orientation, and present the Taylor cone emitter device to an analytical instrument. A handling system and method for analyzing a sample using the Taylor cone emitter device automated handler are disclosed.